研究者氏名	新美敦子
	ニイミアツコ
URL
所属	藤田医科大学
部署	医学部医学科
職名	准教授
学位	農学(東北大学)
J-Global ID	201601017870445567

研究キーワード

PCNA ,DNAポリメラーゼ ,発がん ,DNA複製 ,DNA修復

研究分野

ライフサイエンス / 腫瘍生物学 /

経歴

2014年10月

2018年3月

群馬大学未来先端研究機構統合腫瘍学研究部門

論文

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CERS6 required for cell migration and metastasis in lung cancer

Motoshi Suzuki Ke Cao Seiichi Kato Naoki Mizutani Kouji Tanaka Chinatsu Arima Mei Chee Tai Norie Nakatani Kiyoshi Yanagisawa Toshiyuki Takeuchi Hanxiao Shi Yasuyoshi Mizutani Atsuko Niimi Tetsuo Taniguchi Takayuki Fukui Kohei Yokoi Keiko Wakahara Yoshinori Hasegawa Yukiko Mizutani Soichiro Iwaki Satoshi Fujii Akira Satou Keiko Tamiya-Koizumi Takashi Murate Mamoru Kyogashima Shuta Tomida Takashi Takahashi

Journal of Cellular and Molecular Medicine 24(20) 11949-11959 2020年9月 [査読有り]

Combined α-methylacyl-CoA racemase inhibition and docetaxel treatment reduce cell proliferation and decrease expression of heat shock protein 27 in androgen receptor-variant-7–positive prostate cancer cells

Atsuhiko Yoshizawa Kiyoshi Takahara Masanobu Saruta Kenji Zennami Takuhisa Nukaya Kosuke Fukaya Manabu Ichino Naohiko Fukami Atsuko Niimi Hitomi Sasaki Mamoru Kusaka Motoshi Suzuki Makoto Sumitomo Ryoichi Shiroki

Prostate International 2020年

© 2020 Background: Disease progression in castrate-resistant prostate cancer (PCa) is most commonly driven by the reactivation of androgen receptor (AR) signaling and involves AR splice variants including ARV7. Materials and methods: We used the A...

Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation.

Yoshihiko Hagiwara Takahiro Oike Atsuko Niimi Motohiro Yamauchi Hiro Sato Siripan Limsirichaikul Kathryn D Held Takashi Nakano Atsushi Shibata

Journal of radiation research 60(1) 69-79 2019年1月 [査読有り]

Photons, such as X- or γ-rays, induce DNA damage (distributed throughout the nucleus) as a result of low-density energy deposition. In contrast, particle irradiation with high linear energy transfer (LET) deposits high-density energy along the par...

Analysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage.

Yoshihiko Hagiwara Hiro Sato Tiara Bunga Mayang Permata Atsuko Niimi Motohiro Yamauchi Takahiro Oike Takashi Nakano Atsushi Shibata

Human immunology 79(8) 627-631 2018年8月 [査読有り]

Programmed cell death-1 (PD-1) and its ligand (programmed death-ligand 1, PD-L1) are key factors that regulate a cytotoxic immune reaction. Anti-PD-1 therapy provides significant clinical benefits for patients with cancer, even those with advanced...

3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation

Hagiwara Y Niimi A Isono M Yamauchi M Yasuhara T Limsirichaikul S Oike T Sato H Held KD Nakano T Shibata A

Oncotarget 8(65) 109370-109381 2017年12月 [査読有り]

MISC

放射線照射によって生じたDNA二本鎖切断同士のペアリングの制御機構

山内基弘柴田淳史鈴木啓司鈴木正敏新美敦子近藤久義三浦美和平川美弥子辻田啓子山下俊一松田尚樹

日本保健物理学会研究発表会講演要旨集 50th 103 2017年

ATMとDNA‐PKによるDNA二本鎖切断同士の会合の抑制

山内基弘柴田淳史鈴木啓司鈴木正敏新美敦子近藤久義三浦美和平川美弥子山下俊一松田尚樹

原子爆弾後障害研究会特集号 57th 184‐186 2016年9月

Regulation of translesion synthesis in human cells

Alan R. Lehmann Simone Sabbioneda Thomas Goehler Atsuko Niimi Catherine M. Green Marzena Bienko Ivan Dikic

MUTAGENESIS 27(1) 106-106 2012年1月

PCNA Mono-Ubiquitination and Activation of Translesion DNA Polymerases by DNA Polymerase alpha (vol 146, pg 13, 2009)

Motoshi Suzuki Atsuko Niimi Siripan Limsirichaikul Shuta Tomida Qin Miao Huang Shunji Izuta Jiro Usukura Yasutomo Itoh Takashi Hishida Tomohiro Akashi Yoshiyuki Nakagawa Akihiko Kikuchi Youri Pavlov Takashi Murate Takashi Takahashi

JOURNAL OF BIOCHEMISTRY 148(2) 261-261 2010年8月