Nakako Izumi Nakajima Atsuko Niimi Mayu Isono Takahiro Oike Hiro Sato Takashi Nakano Atsushi Shibata
ONCOLOGY REPORTS 38(2) 693-702 2017年8月 [査読有り]
Immunotherapy is expected to be promising as a next generation cancer therapy. Immunoreceptors are often activated constitutively in cancer cells, however, such levels of ligand expression are not effectively recognized by the native immune system...
Chromosome rearrangement is clinically and physiologically important because it can produce oncogenic fusion genes. Chromosome rearrangement requires DNA double-strand breaks (DSBs) at two genomic locations and misrejoining between the DSBs. Befor...
Mayu Isono Atsuko Niimi Takahiro Oike Yoshihiko Hagiwara Hiro Sato Ryota Sekine Yukari Yoshida Shin-Ya Isobe Chikashi Obuse Ryotaro Nishi Elena Petricci Shinichiro Nakada Takashi Nakano Atsushi Shibata
CELL REPORTS 18(2) 520-532 2017年1月 [査読有り]
BRCA1 promoteshomologous recombination (HR) by activating DNA-end resection. By contrast, 53BP1 forms a barrier that inhibits DNA-end resection. Here, we show that BRCA1 promotes DNA-end resection by relieving the 53BP1-dependent barrier. We show ...
In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant carbon ions and cisplatin is unclear. To obtain the information on th...
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