研究者氏名	熊本海生航

URL
所属	藤田医科大学
部署	研究支援推進本部　病態モデル先端医学研究センター
職名	講師
学位	博士(広島大学)
J-Global ID	201701013940448161

研究キーワード

実験動物 ,生殖細胞 ,疾患モデル ,嚢胞性腎疾患 ,一次繊毛

研究分野

ライフサイエンス / 病態医化学 /

論文

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Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung

Shakibur Rahman Nobuyuki Kondo Kazue Yoneda Teruhisa Takuwa Masaki Hashimoto Hayato Orui Yoshitomo Okumura Fumihiro Tanaka Kanako Kumamoto Mohammad Golam Mostafa Golam Mohiuddin Akbar Chowdhury Akramul Haque Seiki Hasegawa

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 19(1) 45-49 2014年2月 [査読有り]

Background Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patient...

Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement

Masami Yamada Kanako Kumamoto Shintaro Mikuni Yoshiyuki Arai Masataka Kinjo Takeharu Nagai Yoshikazu Tsukasaki Tomonobu M. Watanabe Mitsuru Fukui Mingyue Jin Shiori Toba Shinji Hirotsune

NATURE COMMUNICATIONS 4 2033 2013年6月 [査読有り]

Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of microtubules. We previously demonstrated that LIS1 forms an idling complex with dynein, which is transported to the plus ends of microtubules by kinesin mo...

Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly.

Shiori Toba Yasuhisa Tamura Kanako Kumamoto Masami Yamada Keizo Takao Satoko Hattori Tsuyoshi Miyakawa Yosky Kataoka Mitsuyoshi Azuma Kiyoshi Hayasaka Masano Amamoto Keiko Tominaga Anthony Wynshaw-Boris Hideki Wanibuchi Yuichiro Oka Makoto Sato Mitsuhiro Kato Shinji Hirotsune

Scientific reports 3 1224-1224 2013年 [査読有り]

Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1⁺/⁻ mice, impaired behavioral performance and improvemen...

Activation of Aurora-A Is Essential for Neuronal Migration via Modulation of Microtubule Organization

Takako Takitoh Kanako Kumamoto Chen-Chi Wang Makoto Sato Shiori Toba Anthony Wynshaw-Boris Shinji Hirotsune

JOURNAL OF NEUROSCIENCE 32(32) 11050-11066 2012年8月 [査読有り]

Neuronal migration is a critical feature to ensure proper location and wiring of neurons during cortical development. Postmitotic neurons migrate from the ventricular zone into the cortical plate to establish neuronal lamina in an "inside-out" gra...

Engulfment of spermatozoa by cumulus cells and the role of CD36

X. Z. Yang K. Kumamoto A. Hasegawa S. Komori K. Koyama

JOURNAL OF REPRODUCTIVE IMMUNOLOGY 88(1) 24-31 2011年1月 [査読有り]

The function of cumulus cells after sperm penetration is not well understood. The present study examined the phagocytic action of cumulus cells on sperm after dispersion of cumulus-oocyte complexes. In a co-incubation system of cauda sperm and cum...