Journal of neurochemistry 157(3) 642-655 2020年4月 [査読有り]
Successful completion of daily activities relies on the ability to select the relevant features of the environment for memory and recall. Disruption to these processes can lead to various disorders, such as attention-deficit hyperactivity disorder...
Qiaohui Lu   Akihiro Mouri   Yang Yang   Kazuo Kunisawa   Tomoaki Teshigawara   Mami Hirakawa   Yuko Mori   Yasuko Yamamoto   Zou Libo   Toshitaka Nabeshima   Kuniaki Saito   
Behavioural brain research 372 112053-112053 2019年10月 [査読有り]
Accumulating evidence shows that stressful events evoke molecular alterations in the brain, considered a pathology in major depressive disorder (MDD). However, the abnormalities of neurotransmissions as well as intracellular signaling pathways aff...
Tryptophan metabolism is important to induce immune tolerance in tumors. To date, 3 types of tryptophan-metabolizing enzymes have been identified: indoleamine 2,3-dioxygenase 1 and 2 (IDO1 and IDO2) and tryptophan 2,3-dioxygenase 2. Numerous studi...
The enzyme kynurenine aminotransferase (KAT) catalyses the conversion of kynurenine (KYN) to kynurenic acid (KYNA). Although the isozymes KAT1-4 have been identified, KYNA is mainly produced by KAT2 in brain tissues. KNYA is an antagonist of N-met...