Kazuo Kunisawa   Takeshi Shimizu   Itaru Kushima   Branko Aleksic   Daisuke Mori   Yasuyuki Osanai   Kenta Kobayashi   Anna M Taylor   Manzoor A Bhat   Akiko Hayashi   Hiroko Baba   Norio Ozaki   Kazuhiro Ikenaka   
Journal of neurochemistry 147(3) 395-408 2018年11月 [査読有り]
Myelinated axons segregate the axonal membrane into four defined regions: the node of Ranvier, paranode, juxtaparanode, and internode. The paranodal junction consists of specific component proteins, such as neurofascin155 (NF155) on the glial side...
Indoleamine 2,3-dioxygenase 2 (Ido2) is a recently identified catalytic enzyme in the tryptophan-kynurenine pathway that is expressed primarily in monocytes and dendritic cells. To elucidate the biological role of Ido2 in immune function, we intro...
European journal of pharmacology 796 122-130 2017年2月 [査読有り]
GABA mediated neuronal system regulates hippocampus-dependent memory and stress responses by controlling plasticity and neuronal excitability. Here, we demonstrate that betaine ameliorates water-immersion restraint stress (WIRS)-induced memory imp...
Behavioural brain research 292 36-43 2015年10月 [査読有り]
Betaine plays important roles that include acting as a methyl donor and converting homocysteine (Hcy) to methionine. Elevated plasma Hcy levels are known as hyperhomocysteinemia (HHcy) and contribute to impairments of learning and memory. Although...