研究者氏名	竹内俊幸

URL
所属	藤田医科大学
部署	医学部医学科分子腫瘍学
職名	助教
学位	博士(生命科学)(鳥取大学)
J-Global ID	201801008046891200

研究キーワード

腫瘍 ,転写因子 ,遺伝子発現

研究分野

ライフサイエンス / 分子生物学 /

経歴

2017年10月

現在

藤田医科大学医学部分子腫瘍学助教

2006年3月

2017年9月

株式会社Oncomics 研究部課長

2001年7月

2006年2月

社団法人バイオ産業情報化コンソシーアム特別研究員

2001年4月

2001年6月

鳥取大学医学部研究生

学歴

1998年4月

2001年3月

鳥取大学大学院医学系研究科博士後期課程

1996年4月

1998年3月

鳥取大学大学院医学系研究科博士前期課程

1992年4月

1996年3月

鳥取大学医学部生命科学科

論文

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CERS6 required for cell migration and metastasis in lung cancer.

Motoshi Suzuki Ke Cao Seiichi Kato Naoki Mizutani Kouji Tanaka Chinatsu Arima Mei Chee Tai Norie Nakatani Kiyoshi Yanagisawa Toshiyuki Takeuchi Hanxiao Shi Yasuyoshi Mizutani Atsuko Niimi Tetsuo Taniguchi Takayuki Fukui Kohei Yokoi Keiko Wakahara Yoshinori Hasegawa Yukiko Mizutani Soichiro Iwaki Satoshi Fujii Akira Satou Keiko Tamiya-Koizumi Takashi Murate Mamoru Kyogashima Shuta Tomida Takashi Takahashi

Journal of cellular and molecular medicine 24(20) 11949-11959 2020年9月 [査読有り]

Sphingolipids constitute a class of bio-reactive molecules that transmit signals and exhibit a variety of physical properties in various cell types, though their functions in cancer pathogenesis have yet to be elucidated. Analyses of gene expressi...

Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes.

Chisato Inoue Sayaka Sobue Naoki Mizutani Yoshiyuki Kawamoto Yuji Nishizawa Masatoshi Ichihara Toshiyuki Takeuchi Fumihiko Hayakawa Motoshi Suzuki Tetsuro Ito Yoshinori Nozawa Takashi Murate

Nagoya journal of medical science 82(2) 261-280 2020年5月 [査読有り]

Resveratrol (RSV) has recently attracted keen interest because of its pleiotropic effects. It exerts a wide range of health-promoting effects. In addition to health-promoting effects, RSV possesses anti-carcinogenic activity. However, a non-physio...

Seven-signal proteomic signature for detection of operable pancreatic ductal adenocarcinoma and their discrimination from autoimmune pancreatitis.

Kiyoshi Yanagisawa Shuta Tomida Keitaro Matsuo Chinatsu Arima Miyoko Kusumegi Yukihiro Yokoyama Shigeru B H Ko Nobumasa Mizuno Takeo Kawahara Yoko Kuroyanagi Toshiyuki Takeuchi Hidemi Goto Kenji Yamao Masato Nagino Kazuo Tajima Takashi Takahashi

International journal of proteomics 2012 510397-510397 2012年 [査読有り]

There is urgent need for biomarkers that provide early detection of pancreatic ductal adenocarcinoma (PDAC) as well as discrimination of autoimmune pancreatitis, as current clinical approaches are not suitably accurate for precise diagnosis. We us...

Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas.

Yasushi Matsuyama Motoshi Suzuki Chinatsu Arima Qin Miao Huang Shuta Tomida Toshiyuki Takeuchi Ryoji Sugiyama Yasutomo Itoh Yasushi Yatabe Hidemi Goto Takashi Takahashi

Molecular carcinogenesis 50(4) 301-9 2011年4月 [査読有り]

We previously identified PSMD2, a subunit of the 19S regulatory complex of proteasomes, as a constituent of a signature associated with the acquisition of metastatic phenotype and poor prognosis in lung cancers. In the present study, we found that...

Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress-response pathways.

Kiyoshi Yanagisawa Hiroyuki Konishi Chinatsu Arima Shuta Tomida Toshiyuki Takeuchi Yukako Shimada Yasushi Yatabe Tetsuya Mitsudomi Hirotaka Osada Takashi Takahashi

Cancer research 70(23) 9949-58 2010年12月 [査読有り]

Various stresses of the tumor microenvironment produced by insufficient nutrients, pH, and oxygen can contribute to the generation of altered metabolic and proliferative states that promote the survival of metastatic cells. Among many cellular str...