Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27(17) 2793-9 2009年6月 [査読有り]
PURPOSE: In order to aid the development of patient-tailored therapeutics, we attempted to identify a relapse-related signature that allows selection of a group of adenocarcinoma patients with a high probability of relapse. PATIENTS AND METHODS: W...
Hiromichi Ebi   Shuta Tomida   Toshiyuki Takeuchi   Chinatsu Arima   Takahiko Sato   Tetsuya Mitsudomi   Yasushi Yatabe   Hirotaka Osada   Takashi Takahashi   
Cancer research 69(9) 4027-35 2009年5月 [査読有り]
There is marked disparity with a slight overlap among prognosis-predictive signatures reported thus far for lung cancers. In this study, we aimed at linking poor prognosis with particular pathways and/or functions of the gene sets involved to bett...
The proneural basic-helix-loop-helix protein achaete-scute homologue 1 (ASH1) is expressed in a very limited spectrum of normal and cancerous cells in a lineage-specific manner, including normal pulmonary neuroendocrine cells and lung cancer cells...
Amplification and overexpression of the miR- 17- 92 microRNAs ( miRNA) cluster at 13q31.3 has recently reported, with pointers to functional involvement in the development of B- cell lymphomas and lung cancers. In the present study, we show that i...
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 24(11) 1679-88 2006年4月 [査読有り]
PURPOSE: This study was conducted to gain insight into the relationship between expression profiles and underlying genetic changes, which are known to be important for the pathogenesis of lung cancers. METHODS: Expression profiles of 18,175 unique...