Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes. In this study, the molecular process in this type of liver inj...
Naohiro Hori   Hiroshi Nakano   Toshiyuki Takeuchi   Hiroyuki Kato   Sayuri Hamaguchi   Mitsuo Oshimura   Kenzo Sato   
The Journal of biological chemistry 277(31) 27960-7 2002年8月 [査読有り]
DNA methylation of an imprinted control region (ICR) directs the allele-specific and reciprocal expression of the mouse H19 and the insulin-like growth factor 2 (Igf2) genes, mediated by controlling enhancer access. The ICR shows enhancer blocking...
Toshiyuki Takeuchi   Seiichi Nakamura   Atsushi Kayasuga   Shun-ichi Isa   Kenzo Sato   
The Journal of Biochemistry 128(6) 1025-1031 2000年12月 [査読有り]
Like such hepatic genes as those for albumin and aldolase B, the rat catalase gene shows markedly reduced expression in carcinogenesis of hepatocytes, Strong silencer activity has been widely observed in the 5'-flanking region of the gene, downstr...
Hiroyuki Toda   Toshiyuki Takeuchi   Naohiro Hori   Keizo Ito   
The Journal of Biochemistry 121(6) 1035-1040 1997年6月 [査読有り]
The rat catalase gene promoter lacks a TATA box, and has eight initiation sites of transcription as well as several GT and CCAAT boxes, To elucidate the mechanism of transcription in this TATA-less promoter, we analyzed nuclear factors binding to ...