Akito Kawai   William C. Shropshire   Masahiro Suzuki   Jovan Borjan   Samuel L. Aitken   William C. Bachman   Christi L. McElheny   Micah M. Bhatti   Ryan K. Shields   Samuel A. Shelburne   Yohei Doi   
mBio 15(2) e02874-23 2024年2月
Ceftazidime-avibactam has a broad spectrum of activity against multidrug-resistant Gram-negative bacteria including carbapenem-resistant Enterobacterales including strains with or without production of serine carbapenemases. After its launch, emer...
William C Shropshire   Bradley T Endres   Jovan Borjan   Samuel L Aitken   William C Bachman   Christi L McElheny   Chin-Ting Wu   Stephanie L Egge   Ayesha Khan   William R Miller   Micah M Bhatti   Pranoti Saharasbhojane   Akito Kawai   Ryan K Shields   Samuel A Shelburne   Yohei Doi   
Journal of Antimicrobial Chemotherapy 78(10) 2442-2450 2023年8月
Abstract
Objectives
To characterize a blaCMY variant associated with ceftazidime/avibactam resistance from a serially collected Escherichia coli isolate.
Methods
A patient with an intra-abdominal infection due to recurrent E. coli was treated ...
Aripiprazole (ARP), an antipsychotic drug, binds more strongly to human serum albumin (HSA) than the other ARP derivatives. In addition, the signs for the extrinsic Cotton effects for HSA complexed with ARP or deschloro-ARP are reversed. In this s...
The effects of myristate on the induced circular dichroism spectra of aripiprazole (ARP) bound to human serum albumin (HSA) were investigated. High concentrations of myristate reversed the Cotton effects induced in the ARP-HSA system. The observed...