研究者氏名	瀬戸孝一

URL
所属	藤田医科大学
部署	研究推進本部　未来共創イノベーションセンター
職名
学位	薬学博士
J-Global ID	201901010015875519

研究分野

情報通信 / 生命、健康、医療情報学 /
ライフサイエンス / 分子生物学 /
ライフサイエンス / 薬系化学、創薬科学 /
ライフサイエンス / 薬系衛生、生物化学 /

経歴

2020年2月

現在

株式会社D&P Labo. 代表取締役社長

2019年4月

現在

藤田医科大学研究支援推進本部産学連携推進センター教授、産学連携コーディネーター

2019年4月

2021年2月

京都大学客員研究員

2014年4月

2020年3月

立教大学理学部兼任講師

1991年4月

2019年3月

ゼリア新薬工業株式会社中央研究所

論文

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Glycosaminoglycan and proteoglycan inhibit the depolymerization of beta(2)-microglobulin amyloid fibrils in vitro

Yamaguchi, I H Suda N Tsuzuike K Seto M Seki Y Yamaguchi K Hasegawa N Takahashi S Yamamoto F Gejyo H Naiki

KIDNEY INTERNATIONAL 64(3) 1080-1088 2003年9月 [査読有り]

Background. Although several kinds of evidence suggest that glycosaminoglycans (GAGs) and proteoglycans (PGs) may contribute to the development of beta(2) -microglobulin-related (Abeta(2) m) amyloidosis, the precise roles of these molecules for th...

Fibrates and statins rapidly and synergistically induce pyruvate dehydrogenase kinase 4 mRNA in the liver and muscles of mice

K Motojima K Seto

BIOLOGICAL & PHARMACEUTICAL BULLETIN 26(7) 954-958 2003年7月 [査読有り]

We previously identified pyruvate dehydrogenase kinase 4 (PDK4) mRNA as a most rapidly induced mRNA by fibrates and suggested the possibility that the coupled induction of PDK4 and reduction of serum triglyceride and fatty acid levels can cause pr...

Analysis of tissue-specific and PPAR-alpha-dependent induction of FABP gene expression in the mouse liver by an in vivo DNA electroporation method

K Fujishiro Y Fukui O Sato K Kawabe K Seto K Motojima

MOLECULAR AND CELLULAR BIOCHEMISTRY 239(1-2) 165-172 2002年10月 [査読有り]

Peroxisome proliferator ( PPAR) ligand Wy14,643 induces liver-fatty acid binding protein ( FABP) spontaneously and heart-FABP gradually, but not intestine-FABP mRNA expression in the mouse liver. These strict regulations have not been reproduced i...

Attenuated apoptosis in H-pylori-colonized gastric mucosa of mongolian gerbils in comparison with mice

H Suzuki M Miyazawa S Nagahashi M Mori K Seto A Kai M Suzuki S Miura H Ishii

DIGESTIVE DISEASES AND SCIENCES 47(1) 90-99 2002年1月 [査読有り]

Although gastric cancer formation with H. pylori in Mongolian gerbils was recently reported, the same inoculation procedure did not result in cancer formation in other animals such as mice. Disturbed regulation of apoptosis and cell proliferation ...

Polaprezinc attenuates the Helicobacter pylori-induced gastric mucosal leucocyte activation in Mongolian gerbils - a study using intravital videomicroscopy

H Suzuki M Mori K Seto M Miyazawa A Kai M Suematsu T Yoneta S Miura H Ishii

ALIMENTARY PHARMACOLOGY & THERAPEUTICS 15(5) 715-725 2001年5月 [査読有り]

Background: We previously demonstrated that Helicobacter pylori colonization evokes gastric mucosal inflammation and an extensive increase in lipid peroxides and glutathione in Mongolian gerbils. Zinc and its derivative, polaprezinc, have been rep...