Y Naito   T Yoshikawa   N Yagi   K Matsuyama   N Yoshida   K Seto   T Yoneta   
DIGESTIVE DISEASES AND SCIENCES 46(4) 845-851 2001年4月 [査読有り]
We examined the roles of lipid peroxidation, neutrophil accumulation, and inflammatory cytokines in the protective effect of polaprezine against aspirin-induced gastric mucosal injury in rats. The intragastric administration of acidified aspirin i...
Polaprezinc, N-(3-aminopropionyl)-L-histidinatozinc, has been shown to stimulate the production of insulin-like growth factor-1 (IGF-1) in mesenchymal cells, the polypeptide playing a role in the gastric epithelial wound repair. The present study ...
DIGESTIVE DISEASES AND SCIENCES 45(6) 1200-1209 2000年6月 [査読有り]
We examined the influence of diabetes mellitus (DM) on the healing of HCl-induced gastric lesions and the healing promoting effect of polaprezinc [N-(3-aminopropionyl)-6-histiclinnto zinc] on these lesions. Studies were performed on rats injected ...
Background: CXC chemokines such as interleukin (IL)-8 are neutrophil chemoattractants, the levels of which increase in Helicobacter pylori-infected gastric mucosa. Many investigators have focused on the chemotactic aspects of IL-8; however, CXC ch...
Alimentary Pharmacology and Therapeutics, Supplement 14(1) 94-100 2000年 [査読有り]
Background: CXC chemokines such as interleukin (IL)-8 are neutrophil chemoattractants, the levels of which increase in Helicobacter pylori-infected gastric mucosa. Many investigators have focused on the chemotactic aspects of IL-8: however, CXC ch...