JOURNAL OF GASTROENTEROLOGY 34 43-46 1999年12月 [査読有り]
We previously reported that NH2Cl induced extensive DNA fragmentation in gastric cells. Polaprezinc, a zinc-carnosine chelate compound, is reported to be a potent antioxidant in gastric mucosa. The present study was designed to examine whether pol...
H Suzuki   M Mori   K Seto   S Nagahashi   C Kawaguchi   A Kai   Y Akiba   M Suzuki   M Suematsu   S Miura   H Ishii   
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 14(11) 1062-1069 1999年11月 [査読有り]
Background: Mongolian gerbils have been reported to be a suitable model for Helicobacter pylori-associated gastric mucosal injury, including gastric cancer. Although ethanol is known to be one of the harmful substances in the gastric mucosa, the r...
The effect of polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc), a novel antiulcer drug containing zinc, on cellular proliferation was studied using cultured cells. In human umbilical vein endothelial cells (HUVEC) or human foreskin fibroblast...
H Suzuki   M Mori   K Seto   AM Kai   C Kawaguchi   M Suzuki   M Suematsu   T Yoneta   S Miura   H Ishii   
FREE RADICAL BIOLOGY AND MEDICINE 26(5-6) 679-684 1999年3月 [査読有り]
Helicobacter pylori colonized gastric mucosa is manifest in a significant neutrophil infiltration with an extensive level of oxyradical formation. Mongolian gerbil is one of the excellent models for H. pylori-infection. The present study was desig...
H Suzuki   K Seto   Y Shinoda   M Mori   Y Ishimura   M Suematsu   H Ishii   
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 276(1) G92-G97 1999年1月 [査読有り]
Although vascular endothelial growth factor (VEGF) plays a role in the growth of hypervascular tumors, mechanisms for paracrine regulation of its receptor expression on vascular endothelial cells remain unknown. This study aimed to investigate whe...