JOURNAL OF VIROLOGY 85(21) 11048-11057 2011年11月 [査読有り]
Influenza A viruses are classified into 16 subtypes according to the serotypes of hemagglutinin (HA). It is generally thought that neutralizing antibodies (Abs) are not broadly cross-reactive among HA subtypes. We examined the repertoire of neutra...
Jun Okada Nobuko Ohshima Ritsuko Kubota-Koketsu Yoshitaka Iba Sayuri Ota Wakana Takase Tetsushi Yoshikawa Toyokazu Ishikawa Yoshizo Asano Yoshinobu Okuno Yoshikazu Kurosawa
JOURNAL OF GENERAL VIROLOGY 92(2) 326-335 2011年2月 [査読有り]
Through extensive isolation of neutralizing mAbs against H3N2 influenza viruses representing the in vivo repertoire in a human donor, we examined the relationships between antigenic drift of influenza virus and protective antibodies generated in a...
Jun Okada Nobuko Ohshima Ritsuko Kubota-Koketsu Sayuri Ota Wakana Takase Masachika Azuma Yoshitaka Iba Naoko Nakagawa Tetsushi Yoshikawa Youichi Nakajima Toyokazu Ishikawa Yoshizo Asano Yoshinobu Okuno Yoshikazu Kurosawa
VIROLOGY 397(2) 322-330 2010年2月 [査読有り]
We tried to reveal the strain specificity of neutralizing mAbs against H3N2 influenza viruses in individuals. A large number of B lymphocytes of a pediatrician were collected by apheresis and two Ab libraries were constructed at 2004 and 2007 by u...
JOURNAL OF IMMUNOLOGICAL METHODS 351(1-2) 1-12 2009年12月 [査読有り]
In order to isolate monoclonal antibodies (mAbs) that bind to tumor-associated antigens (Ags) we developed the following strategy. Using the phage-display Ab library we isolated a large number of mAbs that bind to the surface of human tumor cells....
MICROBES AND INFECTION 11(13) 1029-1036 2009年11月 [査読有り]
Human antibodies specific for HCMV are currently considered as potential anti-HCMV therapeutic agents. In this study, we used it combinatorial human antibody library to isolate and characterize complete human monoclonal antibodies that effectively...
お知らせ・マニュアル
研究推進本部