IMMUNOLOGY AND CELL BIOLOGY 75(2) 217-221 1997年4月 [招待有り]
Construction of libraries of artificial antibodies has been reported by several groups of investigators. Various forms of antibody fused to a surface protein, cpIII, are expressed on the surface of filamentous phage. Since phages that encode desir...
K YASUKAWA T KANEKO Y IBA K HIRAYAMA Y KONDO T SAWADA M SOWA JJL HO YS KIM YS CHUNG
INTERNATIONAL JOURNAL OF ONCOLOGY 6(5) 1047-1051 1995年5月 [査読有り]
A murine monoclonal antibody, designated Nd2, was generated using a purified mucin from the human pancreatic cancer cell line SW1990 as the immunogen. Administration of Nd2 into the patients with pancreatic cancer has shown that Nd2 is of clinical...
New type of plasmids named pEdHCG1 and pEdHC kappa.were constructed. A combination of two plasmids containing the amplified gene product for the variable region of the antibody (Ab) heavy or light chains by the polymerase chain reaction (PCR) was ...
K TAKAGI K YASUKAWA Y IBA Y ISOBE Y SUKETA R KANNAGI K KOHDA M TAKAGI T IMANAKA
JOURNAL OF FERMENTATION AND BIOENGINEERING 79(5) 405-409 1995年 [査読有り]
Starting with a previously established hybridoma producing a monoclonal antibody (F1 alpha 75) against a synthetic glycolipid, in which the carbohydrate moiety was artificially designed to be putatively cancer-specific, we cloned complementary DNA...
JOURNAL OF BIOLOGICAL CHEMISTRY 268(22) 16639-16647 1993年8月 [査読有り]
We constructed a library of 512 kinds of Fv fragment, derivatives of a monoclonal antibody, D1.3, specific for hen egg-white lysozyme, in which a total of nine of the original amino acids were replaced by closely related amino acids at positions i...
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