Makito Tanaka   Marcus O. Butler   Sascha Ansen   Osamu Imataki   Alla Berezovskaya   Lee M. Nadler   Naoto Hirano   
CLINICAL CANCER RESEARCH 17(16) 5392-5401 2011年8月 [査読有り]
Purpose: In previous cancer vaccine clinical trials targeting survivin, induction of specific CD8(+) T-cell responses did not consistently lead to clinical responses. Considering the critical role of CD4(+) T-cell help in generating antitumor immu...
Nishio N   Takahashi Y   Tanaka M   Xu Y   Yoshida N   Sakaguchi H   Doisaki S   Hama A   Muramatsu H   Shimada A   Kojima S   
Marcus O. Butler   Philip Friedlander   Matthew I. Milstein   Mary M. Mooney   Genita Metzler   Andrew P. Murray   Makito Tanaka   Alla Berezovskaya   Osamu Imataki   Linda Drury   Lisa Brennan   Marisa Flavin   Donna Neuberg   Kristen Stevenson   Donald Lawrence   F. Stephen Hodi   Elsa F. Velazquez   Michael T. Jaklitsch   Sara E. Russell   Martin Mihm   Lee M. Nadler   Naoto Hirano   
SCIENCE TRANSLATIONAL MEDICINE 3(80) 80ra34 2011年4月 [査読有り]
Although advanced-stage melanoma patients have a median survival of less than a year, adoptive T cell therapy can induce durable clinical responses in some patients. Successful adoptive T cell therapy to treat cancer requires engraftment of antitu...
Marcus O. Butler   Sascha Ansen   Makito Tanaka   Osamu Imataki   Alla Berezovskaya   Mary M. Mooney   Genita Metzler   Matthew I. Milstein   Lee M. Nadler   Naoto Hirano   
INTERNATIONAL IMMUNOLOGY 22(11) 863-873 2010年11月 [査読有り]
Many preclinical experiments have attested to the critical role of CD4(+) T cell help in CD8(+) cytotoxic T lymphocyte (CTL)-mediated immunity. Recent clinical trials have demonstrated that reinfusion of CD4(+) T cells can induce responses in infe...
ES is a complication that occurs immediately before or at the timing of neutrophil engraftment following autologous or allogeneic SCT. It is characterized by fever, skin rash, and non-cardiac pulmonary infiltrates. We evaluated the incidence, risk...