研究者氏名	小澤洋子
	オザワヨウコ
通称等の別名	小沢洋子
URL	http://ophthal.med.keio.ac.jp/research/rcb.html
所属	藤田医科大学
部署	臨床再生医学
職名	教授
学位	医学博士(慶應義塾大学)
その他の所属	慶應義塾大学医学部眼科学教室
科研費研究者番号	90265885
J-Global ID	200901062629077077

プロフィール

Yoko Ozawa M.D., Ph.D. works as a Chief of the Medical Retina Division (Age-related macular disease; AMD division) and a Vitreoretinal Surgeon, as well as a Lab Chief of the Laboratory of Retinal Cell Biology (RCB lab). Her recent research interest is the aging and neuroprotection of the retina, and its association with oxidative stress and inflammation. One of her missions is to find a neuroprotective treatment for the retinal diseases, such as AMD, diabetic retinopathy, and retinitis pigmentosa. During her training of the vitreoretinal surgery, she has become aware that simple surgical therapies do not always rescue the patients’ retina, and the additional approaches may be required for further improvement of the retinal conditions. Therefore, she joined a basic research lab, the Department of Physiology, Keio University School of Medicine, Prof. Hideyuki Okano’s Lab, for mastering neurobiology of the retina, including development and regeneration. After taking the Ph.D., she returned to Department of Ophthalmology, and started her research for learning the pathophysiology of the retinal diseases and exploring new therapeutic approaches.

研究キーワード

神経保護、老化、酸化ストレス、炎症

研究分野

ライフサイエンス / 眼科学 /

学歴

1986年4月

1992年3月

慶應義塾大学医学部

受賞

2016年

Global Ophthalmology Awards Program Research Award

2007年

慶應義塾大学医学部三四会奨励賞

論文

12 3 4 5 >

Associations between fatty acid intake and diabetic retinopathy in a Japanese population

Mariko Sasaki Kenya Yuki Akiko Hanyuda Kazumasa Yamagishi Kaoru Motomura Toshihide Kurihara Yohei Tomita Kiwako Mori Nobuhiro Ozawa Yoko Ozawa Norie Sawada Kazuno Negishi Kazuo Tsubota Shoichiro Tsugane Hiroyasu Iso

Scientific Reports 13(1) 2023年8月

Abstract

Residents of Chikusei City, aged 40–74 years, underwent systemic and ophthalmological screening, and participants with diabetes were included in this analysis. Dietary intake was assessed using a food frequency questionnaire and calculat...

Association Between Fatty Acid Intakes and Age-Related Macular Degeneration in a Japanese Population: JPHC-NEXT Eye Study.

Tomoyo Yasukawa Mariko Sasaki Kaoru Motomura Kenya Yuki Toshihide Kurihara Yohei Tomita Kiwako Mori Nobuhiro Ozawa Yoko Ozawa Kazumasa Yamagishi Akiko Hanyuda Norie Sawada Kazuo Tsubota Shoichiro Tsugane Hiroyasu Iso

Translational vision science & technology 12(1) 3-3 2023年1月

PURPOSE: To determine the associations between fatty acid intakes and the prevalence of age-related macular degeneration (AMD) under a population-based cross-sectional study. METHODS: Residents of Chikusei City aged ≥40 years underwent systemic an...

Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa.

Yoko Ozawa Eriko Toda Kohei Homma Hideto Osada Norihiro Nagai Kazuo Tsubota Hideyuki Okano

Cells 11(9) 2022年4月

Retinitis pigmentosa (RP) is a hereditary blinding disease characterized by gradual photoreceptor death, which lacks a definitive treatment. Here, we demonstrated the effect of 4-phenylbutyric acid (PBA), a chemical chaperon that can suppress endo...

Non-Perfusion Area Index for Prognostic Prediction in Diabetic Retinopathy

Ofuji Y* Katada Y* Tomita Y Nagai N Sonobe H Watanabe K Shinoda H Ozawa Y Negishi K Tsubota K Kurihara T†

Life. 12(4) 542-542 2022年4月 [査読有り]

Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study

Naohiko Aketa Miki Uchino Motoko Kawashima Yuichi Uchino Kenya Yuki Yoko Ozawa Mariko Sasaki Kazumasa Yamagishi Norie Sawada Shoichiro Tsugane Kazuo Tsubota Hiroyasu Iso

Scientific Reports 11(1) 2021年12月

<title>Abstract</title>This population-based cross-sectional study was performed to determine the mean corneal endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX), and their associations with myopia in Japanese ad...