Yoko Ozawa M.D., Ph.D. works as a Chief of the Medical Retina Division (Age-related macular disease; AMD division) and a Vitreoretinal Surgeon, as well as a Lab Chief of the Laboratory of Retinal Cell Biology (RCB lab). Her recent research interest is the aging and neuroprotection of the retina, and its association with oxidative stress and inflammation. One of her missions is to find a neuroprotective treatment for the retinal diseases, such as AMD, diabetic retinopathy, and retinitis pigmentosa. During her training of the vitreoretinal surgery, she has become aware that simple surgical therapies do not always rescue the patients’ retina, and the additional approaches may be required for further improvement of the retinal conditions. Therefore, she joined a basic research lab, the Department of Physiology, Keio University School of Medicine, Prof. Hideyuki Okano’s Lab, for mastering neurobiology of the retina, including development and regeneration. After taking the Ph.D., she returned to Department of Ophthalmology, and started her research for learning the pathophysiology of the retinal diseases and exploring new therapeutic approaches.
研究キーワード
神経保護、老化、酸化ストレス、炎症
研究分野
ライフサイエンス / 眼科学 /
学歴
1986年4月
-
1992年3月
慶應義塾大学 医学部
受賞
2016年
Global Ophthalmology Awards Program Research Award
Journal of Clinical Medicine 10(17) 3944-3944 2021年8月
Purpose: To investigate the risk factors for the development of proliferative vitreoretinopathy grade C (PVR-C), independent of prior surgical invasion. Methods: Patients who underwent surgery for rhegmatogenous retinal detachment were prospective...
Journal of Clinical Medicine 10(10) 2178-2178 2021年5月
To assess the hypofluorescent foci (HFF) on late-phase indocyanine green angiography (ICGA) in central serous chorioretinopathy (CSC) using short-wavelength fundus autofluorescence (SW-FAF), near-infrared autofluorescence (NIR-AF), and fluorescein...
Hideto Osada   Eriko Toda   Kohei Homma   Naymel A Guzman   Norihiro Nagai   Mamoru Ogawa   Kazuno Negishi   Makoto Arita   Kazuo Tsubota   Yoko Ozawa   
Cell death & disease 12(5) 458-458 2021年5月
Lipid metabolism-related gene mutations can cause retinitis pigmentosa, a currently untreatable blinding disease resulting from progressive neurodegeneration of the retina. Here, we demonstrated the influence of adiponectin receptor 1 (ADIPOR1) de...
Hirohiko Kawashima   Yoko Ozawa   Eriko Toda   Kohei Homma   Hideto Osada   Toshio Narimatsu   Norihiro Nagai   Kazuo Tsubota   
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34(4) 5016-5026 2020年4月
Progression of blinding diseases, such as age-related macular degeneration, is accelerated by light exposure. However, no particular intervention is applied to the photostress. Here, we report neuroprotective effects of the adenosine monophosphate...