Yoko Ozawa M.D., Ph.D. works as a Chief of the Medical Retina Division (Age-related macular disease; AMD division) and a Vitreoretinal Surgeon, as well as a Lab Chief of the Laboratory of Retinal Cell Biology (RCB lab). Her recent research interest is the aging and neuroprotection of the retina, and its association with oxidative stress and inflammation. One of her missions is to find a neuroprotective treatment for the retinal diseases, such as AMD, diabetic retinopathy, and retinitis pigmentosa. During her training of the vitreoretinal surgery, she has become aware that simple surgical therapies do not always rescue the patients’ retina, and the additional approaches may be required for further improvement of the retinal conditions. Therefore, she joined a basic research lab, the Department of Physiology, Keio University School of Medicine, Prof. Hideyuki Okano’s Lab, for mastering neurobiology of the retina, including development and regeneration. After taking the Ph.D., she returned to Department of Ophthalmology, and started her research for learning the pathophysiology of the retinal diseases and exploring new therapeutic approaches.
研究キーワード
神経保護、老化、酸化ストレス、炎症
研究分野
ライフサイエンス / 眼科学 /
学歴
1986年4月
-
1992年3月
慶應義塾大学 医学部
受賞
2016年
Global Ophthalmology Awards Program Research Award
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34(8) 10778-10800 2020年7月 [査読有り]
Chronic graft-vs-host disease (cGVHD) is a multifactorial inflammatory disease that affects patients undergoing hematopoietic stem cell transplantation. Multiple organs, including the lacrimal glands (LGs), are negatively affected by cGVHD and los...
Randomized controlled studies have shown that antioxidative supplements are effective in suppressing the progression of age-related macular degeneration and visual display terminal syndrome. However, effects of their general use in the real-world ...
Nagai N   Suzuki M   Uchida A   Kurihara T   Ban N   Minami S   Shinoda H   Tsubota K   Ozawa Y†   
Nagai N   Minami S   Suzuki M   Shinoda H   Kurihara T   Sonobe H   Watanabe K   Uchida A   Ban N   Tsubota K   Ozawa Y†   
Nagai N   Asato T   Minami S   Suzuki M   Shinoda H   Kurihara T   Sonobe H   Watanabe K   Uchida A   Ban N   Tsubota K   Ozawa Y†   
Hirohiko Kawashima   Yoko Ozawa   Eriko Toda   Kohei Homma   Hideto Osada   Toshio Narimatsu   Norihiro Nagai   Kazuo Tsubota   
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34(4) 5016-5026 2020年4月
Progression of blinding diseases, such as age-related macular degeneration, is accelerated by light exposure. However, no particular intervention is applied to the photostress. Here, we report neuroprotective effects of the adenosine monophosphate...