NAGOYA JOURNAL OF MEDICAL SCIENCE 84(1) 80-90 2022年2月
More than 40% of Japanese patients with multiple myeloma (MM) are over 75 years of age at diagnosis. Regardless of the treatment benefits, complications and relapses obstruct long-term survival. We conducted a phase II, open-label, single-arm, mul...
Epileptic disorders : international epilepsy journal with videotape 24(1) 82-94 2022年2月 [査読有り]
OBJECTIVE: To examine the current medical and psychosocial status of patients with epilepsy, aiming to facilitate appropriate application of the Intractable/Rare Diseases Act of Japan. METHODS: By analysing the cross-sectional data of patients reg...
Mitsuhiro Kato Akiko Kada Hideaki Shiraishi Jun Tohyama Eiji Nakagawa Yukitoshi Takahashi Tomoyuki Akiyama Akiyoshi Kakita Noriko Miyake Atsushi Fujita Akiko M Saito Yushi Inoue
Annals of clinical and translational neurology 9(2) 181-192 2022年2月
OBJECTIVE: To determine whether sirolimus, a mechanistic target of rapamycin (mTOR) inhibitor, reduces epileptic seizures associated with focal cortical dysplasia (FCD) type II. METHODS: Sixteen patients (aged 6-57 years) with FCD type II received...
The genotypes of vitamin K epoxide reductase complex 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) can influence therapeutic warfarin doses. Conversely, nongenetic factors, especially renal function, are associated with warfarin maintenance doses; h...
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