JOURNAL OF PHARMACOLOGICAL SCIENCES 93(3) 265-271 2003年11月 [査読有り]
Tetrahydrobiopterin (BH4) acts as an essential cofactor for the enzymatic activity of nitric oxide (NO) synthases. Biosynthesis of the cofactor BH4 starts from GTP and requires 3 enzymatic steps, which include GTP cyclohydrolase I (GCH I) catalysi...
We studied the effects of cAMP on cytokine (interferon-gamma plus tumor necrosis factor-alpha)-induced stimulation of tetrahydrobiopterin (BH4) synthesis in human umbilical vein endothelial cells (HUVEC). The cytokine mixture caused a marked incre...
SI Muramatsu   KI Fujimoto   K Ikeguchi   N Shizuma   K Kawasaki   F Ono   Y Shen   LJ Wang   H Mizukami   A Kume   M Matsumura   Nagatsu, I   F Urano   H Ichinose   T Nagatsu   K Terao   Nakano, I   K Ozawa   
HUMAN GENE THERAPY 13(3) 345-354 2002年2月 [査読有り]
One potential strategy for gene therapy of Parkinson's disease (PD) is the local production of dopamine (DA) in the striatum induced by restoring DA-synthesizing enzymes. In addition to tyrosine hydroxylase (TH) and aromatic-L-amino-acid deca...
JOURNAL OF BIOLOGICAL CHEMISTRY 276(44) 41150-41160 2001年11月 [査読有り]
(6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase (TH), tryptophan hydroxylase, phenylalanine hydroxylase, and nitric-oxide synthase. These enzymes synthesize neurotransmitters, e.g. catecholamines,...
JOURNAL OF BIOLOGICAL CHEMISTRY 270(17) 10062-10071 1995年4月
GTP cyclohydrolase I is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin in mammals. Previously, we reported three species of human GTP cyclohydrolase I cDNA in a human liver cDNA library (Togari, A., Ichinose, H., Ma...
T OHYE   H ICHINOSE   M OGAWA   M YOSHIDA   T NAGATSU   
NEURODEGENERATION 4(1) 81-85 1995年3月
Monkeys are known to be highly susceptible to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) which produces parkinsonism, as in humans. We have previously reported that only monkeys and humans have multiple isoforms of tyrosine hydroxylase...
Hiroshi Ichinose, Daigo Homma, Chiho Sumi-Ichinose, Takahide Nomura, Kazunao Kondo(担当:共著, 範囲:Advances in Pharmacology 68 : A New Era of Catecholamines in the Laboratory and Clinic (Lee E. Eiden Ed))
C. Sumi-Ichinose, F. Urano, R. Kuroda, T. Ohye, M. Kojima, M. Tazawa, H. Shiraishi, K. Ikemoto, Y. Hagino, T. Nagatsu, T. Nomura, H. Ichinose(担当:共著, 範囲:Pterins, Folates and Neurotransmitters in Molecular Medicine,(Blau N., and Thony B Eds))
Sumi-Ichinose C, Urano F, Kojima M, Kuroda R, Shiraishi H, Nomura T, Ichinose H(担当:共著, 範囲:Catecholamine research: From molecular insights to clinical medicine (Advances in Behavioral Biology , 53)(Nagatsu T., Nabeshima T., McCarty R., Goldstein S. D. , Eds))