The causative gene for hereditary progressive dystonia with marked diurnal fluctuation/dopa-responsive dystonia (HPD/DRD) was discovered in 1994 to be guanosine triphosphate (GTP) cyclohydrolase I, an enzyme involved in tetrahydrobiopterin biosynt...
A full-length cDNA clone for GTP cyclohydrolase I (EC 3.5.4.16) was isolated from a Tetrahymena pyriformis cDNA library by plaque hybridization. The nucleotide sequence determination revealed that the length of the cDNA insert was 1516 bp. The cod...
Y. Shen   I. Nagatsu   F. Urano   T. Suzuki   H. Ichinose   T. Nagatsu   J. Monahan   I. Nakano   K. Ozawa   S. I. Muramatsu   K. Ikeguchi   K. I. Fujimoto   D. S. Fan   M. Ogawa   H. Mizukami   M. Urabe   A. Kume   
Human Gene Therapy 11(11) 1509-1519 2000年7月 [査読有り]
Parkinson's disease (PD), a neurological disease suited to gene therapy, is biochemically characterized by a severe decrease in the dopamine content of the striatum. One current strategy for gene therapy of PD involves local production of dopamine...
Nurr1 is a member of the nuclear receptor superfamily of transcription factors that is expressed predominantly in the central nervous system, including developing dopaminergic neurons. Recently, it was demonstrated that Nurr1 is critical for midbr...
JOURNAL OF BIOLOGICAL CHEMISTRY 270(17) 10062-10071 1995年4月
GTP cyclohydrolase I is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin in mammals. Previously, we reported three species of human GTP cyclohydrolase I cDNA in a human liver cDNA library (Togari, A., Ichinose, H., Ma...
T OHYE   H ICHINOSE   M OGAWA   M YOSHIDA   T NAGATSU   
NEURODEGENERATION 4(1) 81-85 1995年3月
Monkeys are known to be highly susceptible to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) which produces parkinsonism, as in humans. We have previously reported that only monkeys and humans have multiple isoforms of tyrosine hydroxylase...
Hiroshi Ichinose, Daigo Homma, Chiho Sumi-Ichinose, Takahide Nomura, Kazunao Kondo(担当:共著, 範囲:Advances in Pharmacology 68 : A New Era of Catecholamines in the Laboratory and Clinic (Lee E. Eiden Ed))
C. Sumi-Ichinose, F. Urano, R. Kuroda, T. Ohye, M. Kojima, M. Tazawa, H. Shiraishi, K. Ikemoto, Y. Hagino, T. Nagatsu, T. Nomura, H. Ichinose(担当:共著, 範囲:Pterins, Folates and Neurotransmitters in Molecular Medicine,(Blau N., and Thony B Eds))
Sumi-Ichinose C, Urano F, Kojima M, Kuroda R, Shiraishi H, Nomura T, Ichinose H(担当:共著, 範囲:Catecholamine research: From molecular insights to clinical medicine (Advances in Behavioral Biology , 53)(Nagatsu T., Nabeshima T., McCarty R., Goldstein S. D. , Eds))