T Ohye   T Hori   S Katoh   T Nagatsu   H Ichinose   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 251(2) 597-602 1998年10月 [査読有り]
Sepiapterin reductase (SPR) catalyzes the final step of the biosynthetic pathway of tetrahydrobiopterin, which is an essential cofactor for aromatic amino acid hydroxylases and nitric oxide synthases. To aid the analysis of any possible human dise...
We first identified GTP cyclohydrolase I activity (EC 3.5.4.16) in the ciliated protozoa, Tetrahymena pyriformis. The V-max value of the enzyme in the cellular extract of T. pyriformis was 255 pmol mg(-1) protein h(-1). Michaelis-Menten kinetics i...
Studies were conducted to clarify the effects of nitric oxide donors NOR 3 ((+/-)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide, FK409), SIN-1 (3-morpholinosydnonimine) and SNAP (S-nitroso-N-acetylpenicillamine) on the accumulation of cGMP ...
C Sumi-Ichinose   H Ichinose   D Metzger   P Chambon   
MOLECULAR AND CELLULAR BIOLOGY 17(10) 5976-5986 1997年10月 [査読有り]
The yeast and animal SNF-SWI and related multiprotein complexes are thought to play an important role in processes, such as transcription factor binding to regulatory elements, which require nucleosome remodeling in order to relieve the repressing...
T Nagatsu   H Ichinose   T Ohye   
BIOGENIC AMINES 12(2) 117-123 1996年
Since the discovery of N-methyl-4-phentl-1 2, 3, 6-tetrahydropyridine (MPTP) as a parkinsonism-producing, dopaminergic neurotoxin, efforts have been made to find MPTP-like neurotoxins in the brain of parkinsonism patients. Tyrosine hydroxylase (TH...
JOURNAL OF BIOLOGICAL CHEMISTRY 270(17) 10062-10071 1995年4月
GTP cyclohydrolase I is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin in mammals. Previously, we reported three species of human GTP cyclohydrolase I cDNA in a human liver cDNA library (Togari, A., Ichinose, H., Ma...
T OHYE   H ICHINOSE   M OGAWA   M YOSHIDA   T NAGATSU   
NEURODEGENERATION 4(1) 81-85 1995年3月
Monkeys are known to be highly susceptible to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) which produces parkinsonism, as in humans. We have previously reported that only monkeys and humans have multiple isoforms of tyrosine hydroxylase...
Hiroshi Ichinose, Daigo Homma, Chiho Sumi-Ichinose, Takahide Nomura, Kazunao Kondo(担当:共著, 範囲:Advances in Pharmacology 68 : A New Era of Catecholamines in the Laboratory and Clinic (Lee E. Eiden Ed))
C. Sumi-Ichinose, F. Urano, R. Kuroda, T. Ohye, M. Kojima, M. Tazawa, H. Shiraishi, K. Ikemoto, Y. Hagino, T. Nagatsu, T. Nomura, H. Ichinose(担当:共著, 範囲:Pterins, Folates and Neurotransmitters in Molecular Medicine,(Blau N., and Thony B Eds))
Sumi-Ichinose C, Urano F, Kojima M, Kuroda R, Shiraishi H, Nomura T, Ichinose H(担当:共著, 範囲:Catecholamine research: From molecular insights to clinical medicine (Advances in Behavioral Biology , 53)(Nagatsu T., Nabeshima T., McCarty R., Goldstein S. D. , Eds))