JOURNAL OF NEURAL TRANSMISSION 103(1-2) 1-15 1996年 [査読有り]
The human aromatic L-amino acid decarboxylase (AADC) gene is transcribed in a tissue-specific manner by an alternative promoter. In this study using human cultured cell lines, we analyzed the alternative promoter that regulates tissue-specific exp...
JAPANESE JOURNAL OF PHARMACOLOGY 69(2) 173-176 1995年10月 [査読有り]
We examined the metabolic effects of glibenclamide, a potent second-generation sulfonylurea, in isolated rat hepatocytes incubated in the absence of extracellular Ca2+. We first demonstrated in the present study that glibenclamide caused a signifi...
We previously reported four different mutations in the coding region of GTP cyclohydrolase I(GCH-I) gene in patients with hereditary progressive dystonia with marked diurnal fluctuation (HPD). We found two independent new mutations (leucine 79 pro...
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION 101(1-3) 237-242 1995年 [査読有り]
Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the prese...
JOURNAL OF BIOLOGICAL CHEMISTRY 270(17) 10062-10071 1995年4月
GTP cyclohydrolase I is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin in mammals. Previously, we reported three species of human GTP cyclohydrolase I cDNA in a human liver cDNA library (Togari, A., Ichinose, H., Ma...
T OHYE   H ICHINOSE   M OGAWA   M YOSHIDA   T NAGATSU   
NEURODEGENERATION 4(1) 81-85 1995年3月
Monkeys are known to be highly susceptible to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) which produces parkinsonism, as in humans. We have previously reported that only monkeys and humans have multiple isoforms of tyrosine hydroxylase...
Hiroshi Ichinose, Daigo Homma, Chiho Sumi-Ichinose, Takahide Nomura, Kazunao Kondo(担当:共著, 範囲:Advances in Pharmacology 68 : A New Era of Catecholamines in the Laboratory and Clinic (Lee E. Eiden Ed))
C. Sumi-Ichinose, F. Urano, R. Kuroda, T. Ohye, M. Kojima, M. Tazawa, H. Shiraishi, K. Ikemoto, Y. Hagino, T. Nagatsu, T. Nomura, H. Ichinose(担当:共著, 範囲:Pterins, Folates and Neurotransmitters in Molecular Medicine,(Blau N., and Thony B Eds))
Sumi-Ichinose C, Urano F, Kojima M, Kuroda R, Shiraishi H, Nomura T, Ichinose H(担当:共著, 範囲:Catecholamine research: From molecular insights to clinical medicine (Advances in Behavioral Biology , 53)(Nagatsu T., Nabeshima T., McCarty R., Goldstein S. D. , Eds))