The polarization of neurons, which mainly includes the differentiation of axons and dendrites, is regulated by cell-autonomous and non-cell-autonomous factors. In the developing central nervous system, neuronal development occurs in a heterogeneou...
JOURNAL OF NEUROSCIENCE 33(33) 13270-13285 2013年8月 [査読有り]
Axon formation is one of the most important events in neuronal polarization and is regulated by signaling molecules involved in cytoskeletal rearrangement and protein transport. We previously found that Partition-defective 3 (Par3) is associated w...
Shinichi Nakamuta Yasuhiro Funahashi Takashi Namba Nariko Arimura Marina R. Picciotto Hiroshi Tokumitsu Thomas R. Soderling Akira Sakakibara Takaki Miyata Hiroyuki Kamiguchi Kozo Kaibuchi
SCIENCE SIGNALING 4(199) ra76 2011年11月 [査読有り]
Neurons are highly polarized cells that have structurally distinct processes-the axons and dendrites-that differentiate from common immature neurites. In cultured hippocampal neurons, one of these immature neurites stochastically initiates rapid e...
Neurons are functionally and morphologically polarized and possess two distinct types of neurites: axons and dendrites. Key molecules for axon formation are transported along microtubules and accumulated at the distal end of the nascent axons. In ...
JOURNAL OF NEUROCHEMISTRY 111(2) 380-390 2009年10月 [査読有り]
The active transport of proteins and organelles is critical for cellular organization and function in eukaryotic cells. A substantial portion of long-distance transport depends on the opposite polarity of the kinesin and dynein family molecular mo...
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