Hideo Hagihara   Hirotaka Shoji   Mahomi Kuroiwa   Isabella A Graef   Gerald R Crabtree   Akinori Nishi   Tsuyoshi Miyakawa   
Molecular Brain 15(1) 94-94 2022年11月 [査読有り]
Calcineurin (Cn), a phosphatase important for synaptic plasticity and neuronal development, has been implicated in the etiology and pathophysiology of neuropsychiatric disorders, including schizophrenia, intellectual disability, autism spectrum di...
CHAMP1 is a gene associated with intellectual disability, which was originally identified as being involved in the maintenance of kinetochore–microtubule attachment. To explore the neuronal defects caused by CHAMP1 deficiency, we establ...
Daiki X Sato   Yukiko U Inoue   Nahoko Kuga   Satoko Hattori   Kensaku Nomoto   Yuki Morimoto   Giovanni Sala   Hideo Hagihara   Takefumi Kikusui   Takuya Sasaki   Yuji Ikegaya   Tsuyoshi Miyakawa   Takayoshi Inoue   Masakado Kawata   
iScience 25(8) 104800 2022年8月 [査読有り]
The human vesicular monoamine transporter 1 (VMAT1) harbors unique substitutions (Asn136Thr/Ile) that affect monoamine uptake into synaptic vesicles. These substitutions are absent in all known mammals, suggesting their contributions to distinct a...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by impairments in social interaction and restricted/repetitive behaviors. The neurotransmitter γ<italic>-</italic>aminobutyric acid (GABA) through GABAA</su...
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Hagihara et al. Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia. Molecular Brain. 2014. 7:41)