Schnurri-2 (Shn-2), an nuclear factor-κB site-binding protein, tightly binds to the enhancers of major histocompatibility complex class I genes and inflammatory cytokines, which have been shown to harbor common variant single-nucleotide polymorphi...
Rick Shin   Katsunori Kobayashi   Hideo Hagihara   Jeffrey H. Kogan   Shinichi Miyake   Katsunori Tajinda   Noah M. Walton   Adam K. Gross   Carrie L. Heusner   Qian Chen   Kouichi Tamura   Tsuyoshi Miyakawa   Mitsuyuki Matsumoto   
Bipolar Disorders 15(4) 405-421 2013年6月 [査読有り]
Objectives There is accumulating evidence to suggest psychiatric disorders, such as bipolar disorder and schizophrenia, share common etiologies, pathophysiologies, genetics, and drug responses with many of the epilepsies. Here, we explored overlap...
Adequate maturation of neurons and their integration into the hippocampal circuit is crucial for normal cognitive function and emotional behavior, and disruption of this process could cause disturbances in mental health. Previous reports have show...
JoVE-Journal of Visualized Experiments (60) 3300 2012年2月 [査読有り]
Forced alternation and left-right discrimination tasks using the T-maze have been widely used to assess working and reference memory, respectively, in rodents. In our laboratory, we evaluated the two types of memory in more than 30 strains of gene...
The dentate gyrus produces new granule neurons throughout adulthood in mammals from rodents to humans. During granule cell maturation, defined markers are expressed in a highly regulated sequential process, which is necessary for directed neuronal...
(Nakajima et al. Similarities of developmental gene expression changes in the brain between human and experimental animals: rhesus monkey, mouse, Zebrafish, and Drosophila. Molecular Brain. 2021.14(1):135;
Hagihara et al. Transcriptomic evidence for immaturity induced by antidepressant fluoxetine in the hippocampus and prefrontal cortex. Neuropsychopharmacology Reports. 2019. 39(2):78-89;
Murano et al. Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders. Communications Biology. 2019. 2:32;
Hagihara et al. Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia. Molecular Brain. 2014. 7:41)