New granule cells are continuously generated in the dentate gyrus of the adult hippocampus. During granule cell maturation, the mechanisms that differentiate new cells not only describe the degree of cell differentiation, but also crucially regula...
JoVE-Journal of Visualized Experiments (33) 1543 2010年 [査読有り]
The hippocampus is one of the most widely studied areas in the brain because of its important functional role in memory processing and learning, its remarkable neuronal cell plasticity, and its involvement in epilepsy, neurodegenerative diseases, ...
Molecular Brain Research 139(2) 258-266 2005年10月 [査読有り]
Epileptic seizures cause severe and long-lasting events on the architecture of the brain, including neuronal cell death, accompanied neurogenesis, reactive gliosis, and mossy fiber sprouting. However, it remains uncertain whether these functional ...
(Nakajima et al. Similarities of developmental gene expression changes in the brain between human and experimental animals: rhesus monkey, mouse, Zebrafish, and Drosophila. Molecular Brain. 2021.14(1):135;
Hagihara et al. Transcriptomic evidence for immaturity induced by antidepressant fluoxetine in the hippocampus and prefrontal cortex. Neuropsychopharmacology Reports. 2019. 39(2):78-89;
Murano et al. Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders. Communications Biology. 2019. 2:32;
Hagihara et al. Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia. Molecular Brain. 2014. 7:41)