研究者氏名	三原圭一朗

URL
所属	藤田医科大学
部署	国際再生医療センター/先進がん免疫療法学
職名
学位	博士（医学）(広島大学)
科研費研究者番号	90363077
J-Global ID	201801010876392945

研究分野

ライフサイエンス / 血液、腫瘍内科学 /

学歴

1992年4月

1996年3月

広島大学医学系研究科内科系専攻

論文

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Effectiveness of 4-1BB-costimulated HER2-targeted chimeric antigen receptor T cell therapy for synovial sarcoma.

Yudai Murayama Hiroyuki Kawashima Nobuhiro Kubo Chansu Shin Yasushi Kasahara Masaru Imamura Naoki Oike Takashi Ariizumi Akihiko Saitoh Keichiro Mihara Hajime Umezu Akira Ogose Chihaya Imai

Translational oncology 14(12) 101227-101227 2021年12月

BACKGROUND: Synovial sarcoma is a rare malignant soft-tissue tumor that is prevalent in adolescents and young adults, and poor prognosis has been reported in patients with metastatic lesions. Chimeric antigen receptor (CAR) T-cell therapy is an em...

Aggressive periodontitis and NOD2 variants.

Noriyoshi Mizuno Kodai Kume Yukiko Nagatani Shinji Matsuda Tomoyuki Iwata Kazuhisa Ouhara Mikihito Kajiya Katsuhiro Takeda Yukiko Matsuda Yui Tada Ryosuke Ohsawa Hiroyuki Morino Keichiro Mihara Tsuyoshi Fujita Hiroyuki Kawaguchi Hideki Shiba Hideshi Kawakami Hidemi Kurihara

Journal of human genetics 65(10) 841-846 2020年10月

Aggressive periodontitis (AgP) occurs at an early age and causes rapid periodontal tissue destruction. Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) encodes a protein with two caspase recruitment domains and eleven leucine-...

Rare primary extramedullary hematopoiesis of the thyroid without intranodular vascularity and mutations in the JAK2, MPL, and calreticulin genes.

Naoe Matsumura Naomi Sasaki Yoko Cho Yutaka Daimaru Takaki Nojima Noriyoshi Mizuno Yoshifumi Takei Keichiro Mihara

Annals of hematology 99(9) 2211-2213 2020年9月

Optineurin regulates osteoblastogenesis through STAT1.

Noriyoshi Mizuno Tomoyuki Iwata Ryosuke Ohsawa Kazuhisa Ouhara Shinji Matsuda Mikihito Kajiya Yukiko Matsuda Kodai Kume Yui Tada Hiroyuki Morino Tetsuya Yoshimoto Yasuyoshi Ueki Keichiro Mihara Yusuke Sotomaru Katsuhiro Takeda Syuichi Munenaga Tsuyoshi Fujita Hiroyuki Kawaguchi Hideki Shiba Hideshi Kawakami Hidemi Kurihara

Biochemical and biophysical research communications 525(4) 889-894 2020年5月

A sophisticated and delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts regulates bone metabolism. Optineurin (OPTN) is a gene involved in primary open-angle glaucoma and amyotrophic lateral sclerosis. Althoug...

Long Noncoding RNA HOTAIR Promotes Epithelial-Mesenchymal Transition and Is a Suitable Target to Inhibit Peritoneal Dissemination in Human Scirrhous Gastric Cancers.

Yoshifumi Takei Toshifumi Hara Akiko Suzuki Keichiro Mihara Kazuyoshi Yanagihara

Pathobiology : journal of immunopathology, molecular and cellular biology 87(5) 277-290 2020年

OBJECTIVES: Scirrhous gastric cancer, which accounts for approximately 10% of all gastric cancers, often disseminates to the peritoneum, leading to intractable cases with poor prognosis. There is an urgent need for new treatment approaches for thi...