<title>Abstract</title>The elevated plus maze test is a widely used test for assessing anxiety-like behavior and screening novel therapeutic agents in rodents. Previous studies have shown that a variety of internal factors and procedural variables...
<title>Abstract</title>
Protrudin is a protein that resides in the membrane of the endoplasmic reticulum and is highly expressed in the nervous system. Although mutations in the human protrudin gene (<italic>ZFYVE27</italic>, also known as <italic...
Atsuki Kawamura Yuta Katayama Masaaki Nishiyama Hirotaka Shoji Kota Tokuoka Yoshifumi Ueta Mariko Miyata Tadashi Isa Tsuyoshi Miyakawa Akiko Hayashi-Takagi Keiichi I Nakayama
Human molecular genetics 29(8) 1274-1291 2020年5月 [査読有り]
Mutations in the gene encoding the chromatin remodeler CHD8 are strongly associated with autism spectrum disorder (ASD). CHD8 haploinsufficiency also results in autistic phenotypes in humans and mice. Although myelination defects have been observe...
Wendy Wenderski Lu Wang Andrey Krokhotin Jessica J Walsh Hongjie Li Hirotaka Shoji Shereen Ghosh Renee D George Erik L Miller Laura Elias Mark A Gillespie Esther Y Son Brett T Staahl Seung Tae Baek Valentina Stanley Cynthia Moncada Zohar Shipony Sara B Linker Maria C N Marchetto Fred H Gage Dillon Chen Tipu Sultan Maha S Zaki Jeffrey A Ranish Tsuyoshi Miyakawa Liqun Luo Robert C Malenka Gerald R Crabtree Joseph G Gleeson
Proceedings of the National Academy of Sciences of the United States of America 117(18) 10055-10066 2020年5月 [査読有り]
Synaptic activity in neurons leads to the rapid activation of genes involved in mammalian behavior. ATP-dependent chromatin remodelers such as the BAF complex contribute to these responses and are generally thought to activate transcription. Howev...
AIMS: Restraint stress is one of the most widely used experimental methods for generating rodent models of stress-induced neuropsychiatric disorders, such as depression and anxiety. Although various types of restraint apparatuses have been used to...
Maturation and integration of neurons and grial cells in the hippocampus is considered to be essential for regulating endocrine, affective, and congnitive functions, and the disruption of such process may cause mental illness. Previously, we have ...
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