Loss-of-function homozygous or compound heterozygous mutations in IL36RN, which encodes interleukin-36 receptor antagonist (IL-36Ra), have been implicated in the pathogenesis of skin disorders. We previously reported that Il36rn-/- mice exhibit an...
Y Tanaka Y Iwata K Saito H Fukushima S Watanabe Y Hasegawa M Akiyama K Sugiura
Journal of the European Academy of Dermatology and Venereology : JEADV 36(2) 295-304 2022年2月 [査読有り]
BACKGROUND: Loss-of-function homozygous or compound heterozygous mutations in IL36RN, which encodes interleukin-36 receptor antagonist (IL-36Ra), has been implicated in the pathogenesis of skin disorders. However, the pathogenic role of IL-36Ra in...
Dermatology and therapy 12(2) 315-328 2022年2月 [査読有り]
Generalised pustular psoriasis (GPP), a severe neutrophilic skin disease characterised by the sudden and widespread eruption of superficial sterile pustules, remains a challenging disease with limited treatment options. The recent discovery of gen...
Takuya Takeichi John Y W Lee Yusuke Okuno Yuki Miyasaka Yuya Murase Takenori Yoshikawa Kana Tanahashi Emi Nishida Tatsuya Okamoto Komei Ito Yoshinao Muro Kazumitsu Sugiura Tamio Ohno John A McGrath Masashi Akiyama
Frontiers in immunology 12 737747-737747 2021年 [査読有り]
Heterozygous mutations in JAK1 which result in JAK-STAT hyperactivity have been implicated in an autosomal dominant disorder that features multi-organ immune dysregulation. This study identifies another previously unreported heterozygous missense ...
膿疱性乾癬と関節症性乾癬のモデルマウス（膿疱性乾癬と関節症性乾癬の病態を細胞・組織レベルで再現。名古屋大との共同研究で作成。Shibata A, et al. J Autoimmun 2017;80:28-38.特許第6654773号 インターロイキン３６受容体アンタゴニスト欠損症の治療薬) ＊本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター（fuji-san@fujita-hu.ac.jp）まで
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