Loss-of-function homozygous or compound heterozygous mutations in IL36RN, which encodes interleukin-36 receptor antagonist (IL-36Ra), have been implicated in the pathogenesis of skin disorders. We previously reported that Il36rn-/- mice exhibit an...
Journal of the European Academy of Dermatology and Venereology : JEADV 36(2) 295-304 2022年2月 [査読有り]
BACKGROUND: Loss-of-function homozygous or compound heterozygous mutations in IL36RN, which encodes interleukin-36 receptor antagonist (IL-36Ra), has been implicated in the pathogenesis of skin disorders. However, the pathogenic role of IL-36Ra in...
Dermatology and therapy 12(2) 315-328 2022年2月 [査読有り]
Generalised pustular psoriasis (GPP), a severe neutrophilic skin disease characterised by the sudden and widespread eruption of superficial sterile pustules, remains a challenging disease with limited treatment options. The recent discovery of gen...
Takuya Takeichi   John Y W Lee   Yusuke Okuno   Yuki Miyasaka   Yuya Murase   Takenori Yoshikawa   Kana Tanahashi   Emi Nishida   Tatsuya Okamoto   Komei Ito   Yoshinao Muro   Kazumitsu Sugiura   Tamio Ohno   John A McGrath   Masashi Akiyama   
Frontiers in immunology 12 737747-737747 2021年 [査読有り]
Heterozygous mutations in JAK1 which result in JAK-STAT hyperactivity have been implicated in an autosomal dominant disorder that features multi-organ immune dysregulation. This study identifies another previously unreported heterozygous missense ...
<文献概要>72歳,女性.40歳頃より全身に皮疹が出現し,近医で入院加療をしたが,確定診断に至ることなく,症状の出現と消退を繰り返していた.71歳時に心筋梗塞で当院入院中に同皮疹が出現し当科を紹介された.初診時,背部や側腹部,両上肢に一部膿疱を伴い落屑を付着した紅斑を認めた.左上腕の紅斑からの生検標本では,角層下に大型の好中球性膿疱がみられ,真皮上層の血管周囲性に炎症性細胞が浸潤し,また膿疱辺縁に多房性のKogoj海綿状膿疱もみられた.遺伝子検索では,IL36RN c. 115+6T>C ...
膿疱性乾癬と関節症性乾癬のモデルマウス(膿疱性乾癬と関節症性乾癬の病態を細胞・組織レベルで再現。名古屋大との共同研究で作成。Shibata A, et al. J Autoimmun 2017;80:28-38.特許第6654773号 インターロイキン36受容体アンタゴニスト欠損症の治療薬) *本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター(fuji-san@fujita-hu.ac.jp)まで