Cancer cells often exhibit extreme sensitivity to splicing inhibitors. We identified food-derived flavonoids, apigenin and luteolin, as compounds that modulate mRNA splicing at the genome-wide level, followed by proliferation inhibition. They bind...
Ryuhei Itoh   Ken-ichi Fujita   Anfeng Mu   Dao Hoang Thien Kim   Tran Tien Tai   Ikuko Sagami   Shigeru Taketani   
FEBS letters 587(14) 2131-6 2013年7月 [査読有り]
Several factors involved in the core circadian rhythm are PAS domain proteins, one of which, neuronal PAS2 (NPAS2), contains a heme-binding motif. It is thought that heme controls the transcriptional activity of core circadian factors BMAL1-NPAS2,...
Bioscience, biotechnology, and biochemistry 76(6) 1248-51 2012年 [査読有り]
A number of proteins complete mRNA processing in the nucleus, thus, inhibitor of mRNA processing is worth finding to analyze the mechanism of mRNA maturation in detail. Here, we established a monitoring system for mRNA processing using a test comp...