Cancer cells often exhibit extreme sensitivity to splicing inhibitors. We identified food-derived flavonoids, apigenin and luteolin, as compounds that modulate mRNA splicing at the genome-wide level, followed by proliferation inhibition. They bind...
Ryuhei Itoh Ken-ichi Fujita Anfeng Mu Dao Hoang Thien Kim Tran Tien Tai Ikuko Sagami Shigeru Taketani
FEBS letters 587(14) 2131-6 2013年7月 [査読有り]
Several factors involved in the core circadian rhythm are PAS domain proteins, one of which, neuronal PAS2 (NPAS2), contains a heme-binding motif. It is thought that heme controls the transcriptional activity of core circadian factors BMAL1-NPAS2,...
Bioscience, biotechnology, and biochemistry 76(6) 1248-51 2012年 [査読有り]
A number of proteins complete mRNA processing in the nucleus, thus, inhibitor of mRNA processing is worth finding to analyze the mechanism of mRNA maturation in detail. Here, we established a monitoring system for mRNA processing using a test comp...
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