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研究者リスト >> 渡邉毅一

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渡邉毅一

研究者氏名	渡邉毅一
	ワタナベキイチ
URL
所属	藤田医科大学
部署	国際再生医療センター
職名	准教授
科研費研究者番号	90392183
J-Global ID	202101015665572510

研究分野

ライフサイエンス / 分子生物学 /
ライフサイエンス / 発生生物学 /
ライフサイエンス / 神経科学一般 /

論文

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Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals.

Mototsugu Eiraku Kiichi Watanabe Mami Matsuo-Takasaki Masako Kawada Shigenobu Yonemura Michiru Matsumura Takafumi Wataya Ayaka Nishiyama Keiko Muguruma Yoshiki Sasai

Cell stem cell 3(5) 519-32 2008年11月

Here, we demonstrate self-organized formation of apico-basally polarized cortical tissues from ESCs using an efficient three-dimensional aggregation culture (SFEBq culture). The generated cortical neurons are functional, transplantable, and capabl...

Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation.

Takafumi Wataya Satoshi Ando Keiko Muguruma Hanako Ikeda Kiichi Watanabe Mototsugu Eiraku Masako Kawada Jun Takahashi Nobuo Hashimoto Yoshiki Sasai

Proceedings of the National Academy of Sciences of the United States of America 105(33) 11796-801 2008年8月

Embryonic stem (ES) cells differentiate into neuroectodermal progenitors when cultured as floating aggregates in serum-free conditions. Here, we show that strict removal of exogenous patterning factors during early differentiation steps induces ef...

Corrigendum: Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells

Fumitaka Osakada Hanako Ikeda Michiko Mandai Takafumi Wataya Kiichi Watanabe Nagahisa Yoshimura Akiori Akaike Yoshiki Sasai Masayo Takahashi

Nature Biotechnology 26(3) 352 2008年3月 [査読有り]

Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells.

Fumitaka Osakada Hanako Ikeda Michiko Mandai Takafumi Wataya Kiichi Watanabe Nagahisa Yoshimura Akinori Akaike Yoshiki Sasai Masayo Takahashi

Nature biotechnology 26(2) 215-24 2008年2月

We previously reported the differentiation of mouse embryonic stem (ES) cells into retinal progenitors. However, these progenitors rarely differentiate into photoreceptors unless they are cultured with embryonic retinal tissues. Here we show the i...

A ROCK inhibitor permits survival of dissociated human embryonic stem cells.

Kiichi Watanabe Morio Ueno Daisuke Kamiya Ayaka Nishiyama Michiru Matsumura Takafumi Wataya Jun B Takahashi Satomi Nishikawa Shin-ichi Nishikawa Keiko Muguruma Yoshiki Sasai

Nature biotechnology 25(6) 681-6 2007年6月

Poor survival of human embryonic stem (hES) cells after cell dissociation is an obstacle to research, hindering manipulations such as subcloning. Here we show that application of a selective Rho-associated kinase (ROCK) inhibitor, Y-27632, to hES ...