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研究者リスト >> 渡邉毅一

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渡邉毅一

研究者氏名	渡邉毅一
	ワタナベキイチ
URL
所属	藤田医科大学
部署	国際再生医療センター
職名	准教授
科研費研究者番号	90392183
J-Global ID	202101015665572510

研究分野

ライフサイエンス / 分子生物学 /
ライフサイエンス / 発生生物学 /
ライフサイエンス / 神経科学一般 /

論文

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Directed differentiation of telencephalic precursors from embryonic stem cells.

Kiichi Watanabe Daisuke Kamiya Ayaka Nishiyama Tomoko Katayama Satoshi Nozaki Hiroshi Kawasaki Yasuyoshi Watanabe Kenji Mizuseki Yoshiki Sasai

Nature neuroscience 8(3) 288-96 2005年3月

We demonstrate directed differentiation of telencephalic precursors from mouse embryonic stem (ES) cells using optimized serum-free suspension culture (SFEB culture). Treatment with Wnt and Nodal antagonists (Dkk1 and LeftyA) during the first 5 d ...

Distinct effects of caudalizing factors on regional specification of embryonic stem cell-derived neural precursors.

Takashi Irioka Kiichi Watanabe Hidehiro Mizusawa Kenji Mizuseki Yoshiki Sasai

Brain research. Developmental brain research 154(1) 63-70 2005年1月

Recent embryological studies have implicated several "caudalizing factors" in the caudal specification of the central nervous system (CNS). In this study, we have examined the effects of three candidate caudalizing factors on neural precursors ind...

Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells.

Kenji Mizuseki Tatsunori Sakamoto Kiichi Watanabe Keiko Muguruma Makoto Ikeya Ayaka Nishiyama Akiko Arakawa Hirofumi Suemori Norio Nakatsuji Hiroshi Kawasaki Fujio Murakami Yoshiki Sasai

Proceedings of the National Academy of Sciences of the United States of America 100(10) 5828-33 2003年5月

To understand the range of competence of embryonic stem (ES) cell-derived neural precursors, we have examined in vitro differentiation of mouse and primate ES cells into the dorsal- (neural crest) and ventralmost (floor plate) cells of the neural ...

Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity.

Hiroshi Kawasaki Hirofumi Suemori Kenji Mizuseki Kiichi Watanabe Fumi Urano Hiroshi Ichinose Masatoshi Haruta Masayo Takahashi Kanako Yoshikawa Shin-Ichi Nishikawa Norio Nakatsuji Yoshiki Sasai

Proceedings of the National Academy of Sciences of the United States of America 99(3) 1580-5 2002年2月

We previously identified a stromal cell-derived inducing activity (SDIA), which induces differentiation of neural cells, including midbrain tyrosine hydroxylase-positive (TH(+)) dopaminergic neurons, from mouse embryonic stem cells. We report here...

Identification of heparin-binding sites in midkine and their role in neurite-promotion.

T Asai K Watanabe K Ichihara-Tanaka N Kaneda S Kojima A Iguchi F Inagaki T Muramatsu

Biochemical and biophysical research communications 236(1) 66-70 1997年7月

Midkine (MK) is a heparin-binding growth factor, which promotes neurite outgrowth in embryonic neurons and enhances their survival. The three dimensional structure of MK clarified by NMR spectroscopy indicates that several basic amino acids are ex...