Nucleobindin (Nuc) was originally identified as a 55 kDa protein that enhanced anti-DNA antibody production in cultures of autoimmune MRL/lpr mouse spleen cells. cDNA cloning and the production of recombinant protein (rNuc) have revealed that rNuc...
K. Miura   M. Hirai   Y. Kanai   Y. Kurosawa   
Genomics 34(2) 181-186 1996年 [査読有り]
Nucleobindin (Nuc) was first identified as a secreted protein of 55 kDa that promotes production of DNA-specific antibodies in lupus-prone MRL/lpr mice. Analysis of cDNA that encoded Nuc revealed that the protein is composed of a signal peptide, a...
Y KANAI   S KYUWA   K MIURA   Y KUROSAWA   
IMMUNOLOGY LETTERS 46(1-2) 207-214 1995年5月 [査読有り]
Long-term administration of low doses (5 mu g) of recombinant nucleobindin (rNuc), which is an MRL/lpr/lpr (MRL/l) mouse-derived DNA-binding protein, induces autoimmunity in both young lupus-prone MRL/+/+ (MRL/n) and normal BALB/c mice. In relatio...
Our previous works have shown that nucleobindin (Nuc) or recombinant (r) Nuc not only augments anti-DNA antibody production in vitro but also accelerates autoimmune response in vivo in MRL/ + / + (MRL/n) mice which are the substrain of autoimmune ...
SN WANG   M MIYAUCHI   N KOSHIKAWA   K MARUYAMA   T KUBOTA   K MIURA   Y KUROSAWA   A AWAYA   Y KANAI   
PATHOLOGY INTERNATIONAL 44(12) 844-849 1994年12月 [査読有り]
A total of 100 gastric adenocarcinomas, comprising 50 cases with lymph node metastasis and 50 cases without lymph node metastasis, were examined for immunohistochemical reactivity with the monoclonal antibody to urokinase-type plasminogen activato...