Naoki Yahata   Hiroko Boda   Ryuji Hata   
Molecular therapy. Methods & clinical development 20 54-68 2021年3月
Various mitochondrial diseases, including mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), are associated with heteroplasmic mutations in mitochondrial DNA (mtDNA). Herein, we refined a previously generated G13513A ...
The Journal of biological chemistry 295(11) 3678-3691 2020年3月 [査読有り]
Alzheimer's disease (AD) is the most common type of dementia, and its pathogenesis is associated with accumulation of β-amyloid (Aβ) peptides. Aβ is produced from amyloid precursor protein (APP) that is sequentially cleaved by β- and γ-secretases....
Naoki Yahata   Yuji Matsumoto   Minoru Omi   Naoki Yamamoto   Ryuji Hata   
SCIENTIFIC REPORTS 7 15557 2017年11月 [査読有り]
Induced pluripotent stem cells (iPSCs) are suitable for studying mitochondrial diseases caused by mitochondrial DNA (mtDNA) mutations. Here, we generated iPSCs from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke...