BACKGROUND: The Grin1 (glutamate receptor, ionotropic, NMDA1) gene expresses a subunit of N-methyl-D-aspartate (NMDA) receptors that is considered to play an important role in excitatory neurotransmission, synaptic plasticity, and brain developmen...
Y. P. Loh   H. Koshimizu   N. X. Cawley   B. Tota   
CURRENT MEDICINAL CHEMISTRY 19(24) 4086-4092 2012年8月 [査読有り]
Serpinins are a family of peptides derived from proteolytic cleavage of the penultimate and the last pair of basic residues at the C-terminus of Chromogranin A. Three forms of naturally occurring serpinin have been found in AtT-20 pituitary cells ...
Bruno Tota   Stefano Gentile   Teresa Pasqua   Eleonora Bassino   Hisatsugu Koshimizu   Niamh X. Cawley   Maria C. Cerra   Y. Peng Loh   Tommaso Angelone   
FASEB JOURNAL 26(7) 2888-2898 2012年7月 [査読有り]
Three forms of serpinin peptides, serpinin (Ala26Leu), pyroglutaminated (pGlu)-serpinin (pGlu23Leu), and serpinin-Arg-Arg-Gly (Ala29Gly), are derived from cleavage at pairs of basic residues in the highly conserved C terminus of chromogranin A (Cg...
FRONTIERS IN BEHAVIORAL NEUROSCIENCE 5 85 2011年12月 [査読有り]
A tumor suppressor gene, Adenornatous polyposis coli (Apc), is expressed in the nervous system from embryonic to adulthood stages, and transmits the Wnt signaling pathway in which schizophrenia susceptibility genes, including T-cell factor 4 (TCF4...
① CRH結合蛋白質の可視化(CRH-BP-pHluorin による生細胞中での輸送・放出過程の可視化。昭和大学、香川大学、横浜薬科大との共同研究。詳細はAdachi et al., J. Neurochem. 2018)
*本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター(fuji-san@fujita-hu.ac.jp)まで