Alicja Woronowicz   Hisatsugu Koshimizu   Su-Youne Chang   Niamh X. Cawley   Joanna M. Hill   Ramona M. Rodriguiz   Daniel Abebe   Caroline Dorfman   Vladimir Senatorov   An Zhou   Zhi-Gang Xiong   William C. Wetsel   Y. Peng Loh   
HIPPOCAMPUS 18(10) 1051-1063 2008年 [査読有り]
Molecules that govern the formation, integrity, and function of the hippocampus remain an important area of investigation. Here we show that absence of the proneuropeptide processing enzyme, carboxypeptidase E (CPE) in CPE knock-out (KO) mice had ...
JOURNAL OF NEUROSCIENCE 27(24) 6417-6427 2007年6月 [査読有り]
Brain-derived neurotrophic factor (BDNF) exerts multiple biological functions in the CNS. Although BDNF can control transcription and protein synthesis, it still remains open to question whether BDNF regulates lipid biosynthesis. Here we show that...
K Nishiyama   A Konishi   C Nishio   K Araki-Yoshida   B Hatanaka   M Kojima   Y Ohmiya   M Yamada   H Koshimizu   
BRAIN RESEARCH BULLETIN 67(1-2) 94-99 2005年9月 [査読有り]
Cystatin C, an inhibitor of cysteine proteinases, is suggested to be involved in oxidative stress-induced apoptosis of cultured CNS neurons and various neuronal diseases in vivo; however, little is known about its mechanism of action. To address t...
S Suzuki   T Numakawa   K Shimazu   H Koshimizu   T Hara   H Hatanaka   L Mei   B Lu   M Kojima   
JOURNAL OF CELL BIOLOGY 167(6) 1205-1215 2004年12月 [査読有り]
Brain-derived neurotrophic factor (BDNF) plays an important role in synaptic plasticity but the underlying signaling mechanisms remain unknown. Here, we show that BDNF rapidly recruits full-length TrkB (TrkB-FL) receptor into cholesterol-rich lipi...
JOURNAL OF BIOLOGICAL CHEMISTRY 279(41) 43245-43253 2004年10月 [査読有り]
Little is known about the role of the integrin-associated protein (IAP, or CD47) in neuronal development and its function in the central nervous system. We investigated neuronal responses in IAP-overexpressing cortical neurons using a virus-gene t...
① CRH結合蛋白質の可視化(CRH-BP-pHluorin による生細胞中での輸送・放出過程の可視化。昭和大学、香川大学、横浜薬科大との共同研究。詳細はAdachi et al., J. Neurochem. 2018)
*本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター(fuji-san@fujita-hu.ac.jp)まで