Journal of Clinical Medicine 12(22) 6997-6997 2023年11月 [査読有り]
Naldemedine is structurally designed to prevent passage across the blood–brain barrier (BBB), resulting in the attenuation of opioid-induced constipation without interfering with the analgesic effects of opioids. However, the influence of brain me...
Biochemical and biophysical research communications 678 179-185 2023年8月 [査読有り]
Extracellular histones induce endothelial damage, resulting in lung haemorrhage; however, the underlying mechanism remains unclear. Factor XIII, as a Ca2+-dependent cross-linking enzyme in blood, mediates fibrin deposition. As another isozyme, tra...
BACKGROUND: Sodium zirconium cyclosilicate, a non-absorbed non-polymer zirconium silicate, is a new potassium binder for hyperkalemia. A previous report showed that administering sodium zirconium cyclosilicate to patients with hyperkalemia allows ...
OBJECTIVES: Patients with cancer, especially those with lung cancer, are at high risk of developing thrombosis. Intralipos® infusion 20% is contraindicated for thrombosis, and there is no consensus on whether it can be safely used in cases of adva...
Takahiro Kato   Tomohiro Mizuno   Masanori Nakanishi   Jeannie K Lee   Shigeki Yamada   Naotake Tsuboi   Kazuo Takahashi   
In vivo (Athens, Greece) 37(3) 1236-1245 2023年5月 [査読有り]
BACKGROUND/AIM: Sepsis is a life-threatening biological condition that induces systemic tissue and organ dysfunction and confers a high mortality risk. Although the use of hydrocortisone in combination with ascorbic acid and thiamine (HAT therapy)...