Journal of immunology (Baltimore, Md. : 1950) 212(7) 1221-1231 2024年4月
Pulmonary fibrosis is a fatal condition characterized by fibroblast and myofibroblast proliferation and collagen deposition. TGF-β plays a pivotal role in the development of pulmonary fibrosis. Therefore, modulation of TGF-β signaling is a promisi...
Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblast...
American journal of respiratory cell and molecular biology 68(2) 201-212 2022年10月 [査読有り]
Asthma is a chronic airway inflammatory disease characterized by airway hyperreactivity (AHR) and eosinophilic airway inflammation. Dendritic cells (DCs) are essential for the development of asthma via presenting allergens, causing Th2 skewing and...
Life Science Alliance 5(6) e202101230-e202101230 2022年6月
Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment (TME). Most CAFs shape the TME toward an immunosuppressive milieu and attenuate the efficacy of immune checkpoint blockade (ICB) therapy. However, the det...
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 65(6) 347-366 2017年6月
Tuft cells (TCs) are minor components of gastrointestinal epithelia, characterized by apical tufts and spool-shaped somas. The lack of reliable TC-markers has hindered the elucidation of its role. We developed site-specific and phosphorylation-sta...
Yi-Peng Han Atsushi Enomoto Yukihiro Shiraki Shen-Qi Wang Xiaoze Wang Shinya Toyokuni Naoya Asai Kaori Ushida Hosne Ara Fumiharu Ohka Toshihiko Wakabayashi Jie Ma Atsushi Natsume Masahide Takahashi
NEURO-ONCOLOGY 19(5) 636-647 2017年5月
The significance of mammalian target of rapamycin complex 1 (mTORC1) activity in the maintenance of cancer stem cells (CSCs) remains controversial. Previous findings showed that mTORC1 activation depleted the population of leukemia stem cells in l...
CD109 is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed in several types of human cancers, particularly squamous cell carcinomas. We previously reported that CD109-deficient mice exhibit epidermal hyperplasia and chr...
Martin Kolev Estefania Nova-Lamperti Simon Freeley Dorota Smolarek Shinjini Chakraborthy Shinji Mii Masahide Takahashi Richard A. Smith Behdad Afzali Claudia Kemper
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