Journal of immunology (Baltimore, Md. : 1950) 212(7) 1221-1231 2024年4月
Pulmonary fibrosis is a fatal condition characterized by fibroblast and myofibroblast proliferation and collagen deposition. TGF-β plays a pivotal role in the development of pulmonary fibrosis. Therefore, modulation of TGF-β signaling is a promisi...
Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblast...
American journal of respiratory cell and molecular biology 68(2) 201-212 2022年10月 [査読有り]
Asthma is a chronic airway inflammatory disease characterized by airway hyperreactivity (AHR) and eosinophilic airway inflammation. Dendritic cells (DCs) are essential for the development of asthma via presenting allergens, causing Th2 skewing and...
Life Science Alliance 5(6) e202101230-e202101230 2022年6月
Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment (TME). Most CAFs shape the TME toward an immunosuppressive milieu and attenuate the efficacy of immune checkpoint blockade (ICB) therapy. However, the det...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 469(4) 816-822 2016年1月 [査読有り]
Exosomes are 50-100-nm-diameter membrane vesicles released from various types of cells. Exosomes retain proteins, mRNAs and miRNAs, which can be transported to surrounding cells. CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, and i...
Aya Muramatsu   Atsushi Enomoto   Takuya Kato   Liang Weng   Keisuke Kuroda   Naoya Asai   Masato Asai   Shinji Mu   Masahide Takahashi   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 463(4) 999-1005 2015年8月 [査読有り]
Girdin is an actin-binding protein that has multiple functions in postnatal neural development and cancer progression. We previously showed that Girdin is a regulator of migration for neuroblasts born from neural stem cells in the subventricular z...
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 100(7) E946-E954 2015年7月 [査読有り]
Context: Central diabetes insipidus (CDI) can be caused by several diseases, but in about half of the patients the etiological diagnosis remains unknown. Lymphocytic infundibulo-neurohypophysitis (LINH) is an increasingly recognized entity among c...
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35(5) 1246-1253 2015年5月
Objective-The accumulation of unfolded protein in the endoplasmic reticulum (ER) initiates an adaptive stress response, termed the unfolded protein response. Previous studies suggested that ER stress might be involved in the formation of neointima...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 461(2) 260-267 2015年5月 [査読有り]
Vascular permeability is regulated by intercellular junction organization of endothelial cells, the dysfunction of which is implicated in numerous pathological conditions. Molecular mechanisms of how endothelial cells regulate intercellular juncti...