Virchows Archiv : an international journal of pathology 480(4) 819-829 2022年4月
CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, whose expression is upregulated in some types of malignant tumors. High levels of CD109 in tumor cells have been reported to correlate with poor prognosis; however, significance of CD1...
Hiroki Kobayashi Krystyna A Gieniec Tamsin R M Lannagan Tongtong Wang Naoya Asai Yasuyuki Mizutani Tadashi Iida Ryota Ando Elaine M Thomas Akihiro Sakai Nobumi Suzuki Mari Ichinose Josephine A Wright Laura Vrbanac Jia Q Ng Jarrad Goyne Georgette Radford Matthew J Lawrence Tarik Sammour Yoku Hayakawa Sonja Klebe Alice E Shin Samuel Asfaha Mark L Bettington Florian Rieder Nicholas Arpaia Tal Danino Lisa M Butler Alastair D Burt Simon J Leedham Anil K Rustgi Siddhartha Mukherjee Masahide Takahashi Timothy C Wang Atsushi Enomoto Susan L Woods Daniel L Worthley
Gastroenterology 162(3) 890-906 2022年3月
BACKGROUND & AIMS: Cancer-associated fibroblasts (CAFs) play an important role in colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However, the cellular origins of CAFs remain unknown, making it challenging to therap...
Cancer-associated fibroblasts (CAFs), a compartment of the tumor microenvironment, were previously thought to be a uniform cell population that promotes cancer progression. However, recent studies have shown that CAFs are heterogeneous and that th...
<title>Abstract</title>The V-shaped arrangement of hair bundles on cochlear hair cells is critical for auditory sensing. However, regulation of hair bundle arrangements has not been fully understood. Recently, defects in hair bundle arrangement we...
Journal of Pathology 244(4) 469-478 2018年4月 [査読有り]
Autoimmune hypophysitis (AH) is thought to be an autoimmune disease characterized by lymphocytic infiltration of the pituitary gland. Among AH pathologies, lymphocytic infundibulo-neurohypophysitis (LINH) involves infiltration of the neurohypophys...
Pathology International 68(4) 241-245 2018年4月 [査読有り]
Embedding of tissue samples that maintains a desired orientation is critical for preparing sections suitable for diagnosis and study objectives. Methods to prepare tissue sections include: (i) paraffin embedding or snap-freezing followed by microt...
Streptozotocin (STZ) has been widely used to induce diabetes in rodents. Strain-dependent variation in susceptibility to STZ has been reported
however, the gene(s) responsible for STZ susceptibility has not been identified. Here, we utilized the ...
Liang Weng Yi-Peng Han Atsushi Enomoto Yasuyuki Kitaura Shushi Nagamori Yoshikatsu Kanai Naoya Asai Jian An Maki Takagishi Masato Asai Shinji Mii Takashi Masuko Yoshiharu Shimomura Masahide Takahashi
PLoS biology 16(3) e2005090 2018年3月
Amino acid signaling mediated by the activation of mechanistic target of rapamycin complex 1 (mTORC1) is fundamental to cell growth and metabolism. However, how cells negatively regulate amino acid signaling remains largely unknown. Here, we show ...
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