Frontiers in Cell and Developmental Biology 9 749924-749924 2021年10月
Fibroblasts synthesise the extracellular matrix (ECM) such as collagen and elastin, the excessive accumulation of which can lead to fibrosis and organ dysfunction under pathological conditions. Cancer-associated fibroblasts (CAFs) are major consti...
Hiroki Kobayashi Krystyna A Gieniec Jia Q Ng Jarrad Goyne Tamsin R M Lannagan Elaine M Thomas Georgette Radford Tongtong Wang Nobumi Suzuki Mari Ichinose Josephine A Wright Laura Vrbanac Alastair D Burt Masahide Takahashi Atsushi Enomoto Daniel L Worthley Susan L Woods
Journal of visualized experiments : JoVE (175) 2021年9月
Hepatic metastasis of colorectal cancer (CRC) is a leading cause of cancer-related death. Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment, play a crucial role in metastatic CRC progression and predict poor pat...
Multiciliated cells (MCCs) in tracheas generate mucociliary clearance through coordinated ciliary beating. Apical microtubules (MTs) play a crucial role in this process by organizing the planar cell polarity (PCP)–dependent orientation of ciliary ...
Mesenchymal stem cells (MSCs) are the likely precursors of multiple lines of mesenchymal cells. The existence of bona fide MSCs with self-renewal capacity and differentiation potential into all mesenchymal lineages, however, has been unclear becau...
Yoshio Nakahara Naozumi Hashimoto Koji Sakamoto Atsushi Enomoto Taylor S Adams Toyoharu Yokoi Norihito Omote Sergio Poli Akira Ando Keiko Wakahara Atsushi Suzuki Masahide Inoue Akitoshi Hara Yasuyuki Mizutani Kazuyoshi Imaizumi Tsutomu Kawabe Ivan O Rosas Masahide Takahashi Naftali Kaminski Yoshinori Hasegawa
The European respiratory journal 58(6) 2021年5月
The prognosis of elderly individuals with idiopathic pulmonary fibrosis (IPF) remains poor. Fibroblastic foci, in which aggregates of proliferating fibroblasts and myofibroblasts are involved, are the pathological hallmark lesions in IPF to repres...
Journal of Pathology 244(4) 469-478 2018年4月 [査読有り]
Autoimmune hypophysitis (AH) is thought to be an autoimmune disease characterized by lymphocytic infiltration of the pituitary gland. Among AH pathologies, lymphocytic infundibulo-neurohypophysitis (LINH) involves infiltration of the neurohypophys...
Pathology International 68(4) 241-245 2018年4月 [査読有り]
Embedding of tissue samples that maintains a desired orientation is critical for preparing sections suitable for diagnosis and study objectives. Methods to prepare tissue sections include: (i) paraffin embedding or snap-freezing followed by microt...
Streptozotocin (STZ) has been widely used to induce diabetes in rodents. Strain-dependent variation in susceptibility to STZ has been reported
however, the gene(s) responsible for STZ susceptibility has not been identified. Here, we utilized the ...
Liang Weng Yi-Peng Han Atsushi Enomoto Yasuyuki Kitaura Shushi Nagamori Yoshikatsu Kanai Naoya Asai Jian An Maki Takagishi Masato Asai Shinji Mii Takashi Masuko Yoshiharu Shimomura Masahide Takahashi
PLoS biology 16(3) e2005090 2018年3月
Amino acid signaling mediated by the activation of mechanistic target of rapamycin complex 1 (mTORC1) is fundamental to cell growth and metabolism. However, how cells negatively regulate amino acid signaling remains largely unknown. Here, we show ...
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