Yoshinori Yasuda Shintaro Iwama Daisuke Sugiyama Takayuki Okuji Tomoko Kobayashi Masaaki Ito Norio Okada Atsushi Enomoto Sachiko Ito Yue Yan Mariko Sugiyama Takeshi Onoue Taku Tsunekawa Yoshihiro Ito Hiroshi Takagi Daisuke Hagiwara Motomitsu Goto Hidetaka Suga Ryoichi Banno Masahide Takahashi Hiroyoshi Nishikawa Hiroshi Arima
Science Translational Medicine 13(593) 2021年5月
Immune-related adverse events induced by anti–programmed cell death–1 antibodies (PD-1-Ab), including destructive thyroiditis (thyroid-irAE), are thought to be caused by activated T cells. However, the T cell subsets that are directly responsible ...
Objective: Owing to variations in the exterior appearances of noncancerous diseases in the oral cavity, clinicians may have difficulty diagnosing oral squamous cell carcinoma (OSCC). Tissue biopsy is confirmatory, but invasive. Therefore, reliable...
We previously reported that ROR1 is a crucial downstream gene for the TTF-1/NKX2-1 lineage-survival oncogene in lung adenocarcinoma, while others have found altered expression of ROR1 in multiple cancer types. Accumulated evidence therefore indica...
Hiroki Kobayashi Krystyna A. Gieniec Josephine A. Wright Tongtong Wang Naoya Asai Yasuyuki Mizutani Tadashi Lida Ryota Ando Nobumi Suzuki Tamsin R.M. Lannagan Jia Q. Ng Akitoshi Hara Yukihiro Shiraki Shinji Mii Mari Ichinose Laura Vrbanac Matthew J. Lawrence Tarik Sammour Kay Uehara Gareth Davies Leszek Lisowski Ian E. Alexander Yoku Hayakawa Lisa M. Butler Andrew C.W. Zannettino M. Omar Din Jeff Hasty Alastair D. Burt Simon J. Leedham Anil K. Rustgi Siddhartha Mukherjee Timothy C. Wang Atsushi Enomoto Masahide Takahashi Daniel L. Worthley Susan L. Woods
Gastroenterology 160(4) 1224-1239.e30 2021年3月
Background & Aims: Cancer-associated fibroblasts (CAFs), key constituents of the tumor microenvironment, either promote or restrain tumor growth. Attempts to therapeutically target CAFs have been hampered by our incomplete understanding of these f...
Journal of Pathology 244(4) 469-478 2018年4月 [査読有り]
Autoimmune hypophysitis (AH) is thought to be an autoimmune disease characterized by lymphocytic infiltration of the pituitary gland. Among AH pathologies, lymphocytic infundibulo-neurohypophysitis (LINH) involves infiltration of the neurohypophys...
Pathology International 68(4) 241-245 2018年4月 [査読有り]
Embedding of tissue samples that maintains a desired orientation is critical for preparing sections suitable for diagnosis and study objectives. Methods to prepare tissue sections include: (i) paraffin embedding or snap-freezing followed by microt...
Streptozotocin (STZ) has been widely used to induce diabetes in rodents. Strain-dependent variation in susceptibility to STZ has been reported
however, the gene(s) responsible for STZ susceptibility has not been identified. Here, we utilized the ...
Liang Weng Yi-Peng Han Atsushi Enomoto Yasuyuki Kitaura Shushi Nagamori Yoshikatsu Kanai Naoya Asai Jian An Maki Takagishi Masato Asai Shinji Mii Takashi Masuko Yoshiharu Shimomura Masahide Takahashi
PLoS biology 16(3) e2005090 2018年3月
Amino acid signaling mediated by the activation of mechanistic target of rapamycin complex 1 (mTORC1) is fundamental to cell growth and metabolism. However, how cells negatively regulate amino acid signaling remains largely unknown. Here, we show ...
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