The group A rotavirus (RVA) genome comprising 11 double-stranded RNAs encodes six structural proteins (VP1-VP4, VP6, and VP7) and six non-structural proteins (NSP1-NSP6). Among these 12 rotaviral proteins, NSP6 has been less studied as to its func...
High salt (HS) intake is known as a risk factor for hypertension and dementia. Prostaglandin E2 (PGE2) has various effects on vascular function and central nervous system via four types of PGE2 receptors (EP1-EP4). However, an involvement of PGE2/...
Kyongtae T. Bae   Kanako Kumamoto   Aya Yoshimura   Masanori Kugita   Shigeo Horie   Tamio Yamaguchi   Junu T. Bae   Shizuko Nagao   
Journal of Nephrology 35(3) 1033-1040 2021年11月 [査読有り]
BACKGROUND: Cystogenesis in polycystic kidney disease (PKD) is likely accelerated by various renal insults, including crystal deposition, that activate renal tubule obstruction and dilation. We developed a capsule-based device that can be applied ...
Journal of Nutritional Science and Vitaminology 67(4) 243-248 2021年8月 [査読有り]
Daily fat and sugar intake has increased in Japan, while total energy intake has decreased. However, the number of type 2 diabetes mellitus patients has increased, and this often causes renal injury characterized by autophagic vacuoles. Although m...
High salt (HS) intake is known as a risk factor for hypertension and dementia. However, an involvement of the brain-peripheral interaction in the HS-induced hypertension and cognitive dysfunction is still unclear. In this study, we confirmed the e...