Increased intracellular cyclic AMP (cAMP) in renal tubular epithelia accelerates the progression of polycystic kidney disease (PKD). Thus, decreasing cAMP levels by an adenylyl cyclase inhibitory G protein activator is considered to be an effectiv...
Daisuke Yoshihara Daisuke Yoshihara Hiroki Kurahashi Miwa Morita Masanori Kugita Yoshiyuki Hiki Harold M. Aukema Tamio Yamaguchi Tamio Yamaguchi James P. Calvet Darren P. Wallace Shizuko Nagao Shizuko Nagao
American Journal of Physiology - Renal Physiology 300(2) 465-474 2011年2月 [査読有り]
In autosomal recessive polycystic kidney disease (ARPKD), progressive enlargement of fluid-filled cysts is due to aberrant proliferation of tubule epithelial cells and transepithelial fluid secretion leading to extensive nephron loss and interstit...
Masanori Kugita Kazuhiro Nishii Miwa Morita Daisuke Yoshihara Daisuke Yoshihara Hiroe Kowa-Sugiyama Kouji Yamada Tamio Yamaguchi Darren P. Wallace James P. Calvet Hiroki Kurahashi Shizuko Nagao
American Journal of Physiology - Renal Physiology 300(1) 177-188 2011年1月 [査読有り]
Han: SPRD Cy is a spontaneous rat model of polycystic kidney disease (PKD) caused by a missense mutation in Pkdr1. Cystogenesis in this model is not clearly understood. In the current study, we performed global gene expression profiling in early-s...
Shizuko Nagao Shizuko Nagao Miwa Morita Masanori Kugita Daisuke Yoshihara Tamio Yamaguchi Tamio Yamaguchi Hiroki Kurahashi James P. Calvet James P. Calvet Darren P. Wallace Darren P. Wallace Darren P. Wallace
American Journal of Physiology - Renal Physiology 299(5) 1078-1086 2010年11月 [査読有り]
Polycystic kidney disease (PKD) in Han:SPRD Cy rats is caused by a missense mutation in Anks6 (also called Pkdr1), leading to an R823W substitution in SamCystin, a protein that contains ankyrin repeats and a sterile alpha motif (SAM). The cellular...
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