International journal of hematology 108(2) 208-212 2018年8月 [査読有り]
Variant chromosomal translocations associated with t(8;21) are observed in 3-4% of acute myeloid leukemia (AML) cases with a RUNX1-RUNX1T1 fusion gene. However, the molecular events that occur in variants of t(8;21) are not well characterized. In ...
Biochemical and biophysical research communications 496(3) 921-926 2018年2月 [査読有り]
Human RNPS1 protein was first identified as a pre-mRNA splicing activator in vitro and RNPS1 regulates alternative splicing in cellulo. RNPS1 was also known as a peripheral factor of the exon junction complex (EJC). Here we show that cellular knoc...
Ohe K   Miyajima S   Tanaka T   Hamaguchi Y   Harada Y   Horita Y   Beppu Y   Ito F   Yamasaki T   Terai H   Mori M   Murata Y   Tanabe M   Abe I   Ashida K   Kobayashi K   Enjoji M   Nomiyama T   Yanase T   Harada N   Utsumi T   Mayeda A   
Frontiers in molecular biosciences 5 52-52 2018年 [査読有り]
Spliceostatin A (SSA) is a methyl ketal derivative of FR901464, a potent antitumor compound isolated from a culture broth of Pseudomonas sp no. 2663. These compounds selectively bind to the essential spliceosome component SF3b, a subcomplex of the...
International journal of molecular sciences 17(10) 2016年10月 [査読有り]
Duchenne muscular dystrophy (DMD) is a severe muscular disorder. It was reported that multiple exon skipping (MES), targeting exon 45-55 of the DMD gene, might improve patients' symptoms because patients who have a genomic deletion of all these ex...
① がん由来細胞を用いた、mRNA再スプライシングを含む異常スプライシングの分子機構の解析、
② ヒトの新規スプライシング因子として再発見されたSPF45の、抗がん多剤耐性への関与機構の解析、
*本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進セン
ター(fuji-san@fujita-hu.ac.jp)まで