International journal of molecular sciences 17(8) 2016年8月 [査読有り]
The exon junction complex (EJC) that is deposited onto spliced mRNAs upstream of exon-exon junctions plays important roles in multiple post-splicing gene expression events, such as mRNA export, surveillance, localization, and translation. However,...
Genes, chromosomes & cancer 55(3) 242-50 2016年3月 [査読有り]
ETV6, which encodes an ETS family transcription factor, is frequently rearranged in human leukemias. We show here that a patient with acute myeloid leukemia with t(7;11)(p15;p15) gained, at the time of relapse, t(11;12)(q12.1;p13) with a split ETV...
Rei Yoshimoto   Akila Mayeda   Minoru Yoshida   Shinichi Nakagawa   
Biochimica et biophysica acta 1859(1) 192-9 2016年1月 [査読有り]
A recent massive parallel sequencing analysis has shown the fact that more than 80% of the human genome is transcribed into RNA. Among many kinds of the non-protein coding RNAs, we focus on the metastasis associated lung adenocarcinoma transcript ...
Makoto K Shimada   Noriko Sasaki-Haraguchi   Akila Mayeda   
International journal of molecular sciences 16(5) 10376-88 2015年5月 [査読有り]
According to the length distribution of human introns, there is a large population of short introns with a threshold of 65 nucleotides (nt) and a peak at 85 nt. Using human genome and transcriptome databases, we investigated the introns shorter th...
① がん由来細胞を用いた、mRNA再スプライシングを含む異常スプライシングの分子機構の解析、
② ヒトの新規スプライシング因子として再発見されたSPF45の、抗がん多剤耐性への関与機構の解析、
*本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進セン
ター(fuji-san@fujita-hu.ac.jp)まで