Hitoshi Suzuki Yuhong Zuo Jinhua Wang Michael Q Zhang Arun Malhotra Akila Mayeda
Nucleic acids research 34(8) e63 2006年5月 [査読有り]
Besides linear RNAs, pre-mRNA splicing generates three forms of RNAs: lariat introns, Y-structure introns from trans-splicing, and circular exons through exon skipping. To study the persistence of excised introns in total cellular RNA, we used thr...
Nucleophosmin (NPM) is a multifunctional phosphoprotein, being involved in ribosome assembly, pre-ribosomal RNA processing, DNA duplication, nucleocytoplasmic protein trafficking, and centrosome duplication. NPM is phosphorylated by several kinase...
Janeen H Trembley Sawako Tatsumi Eiji Sakashita Pascal Loyer Clive A Slaughter Hitoshi Suzuki Hitoshi Endo Vincent J Kidd Akila Mayeda
Molecular and cellular biology 25(4) 1446-57 2005年2月 [査読有り]
Human RNPS1 was originally characterized as a pre-mRNA splicing activator in vitro and was shown to regulate alternative splicing in vivo. RNPS1 was also identified as a protein component of the splicing-dependent mRNP complex, or exon-exon juncti...
Eiji Sakashita Sawako Tatsumi Dieter Werner Hitoshi Endo Akila Mayeda
Molecular and cellular biology 24(3) 1174-87 2004年2月 [査読有り]
Human RNPS1 was originally purified and characterized as a pre-mRNA splicing activator, and its role in the postsplicing process has also been proposed recently. To search for factors that functionally interact with RNPS1, we performed a yeast two...
Genes to cells : devoted to molecular & cellular mechanisms 9(2) 121-30 2004年2月 [査読有り]
Some of mutations in the tau gene, which were found in frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), affect alternative splicing of its exon 10 which encodes one of four microtubule-binding motifs. To examine the mol...
① がん由来細胞を用いた、mRNA再スプライシングを含む異常スプライシングの分子機構の解析、
② ヒトの新規スプライシング因子として再発見されたSPF45の、抗がん多剤耐性への関与機構の解析、
＊本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進セン
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