The hypothalamus is comprised of heterogenous cell populations and includes highly complex neural circuits that regulate the autonomic nerve system. Its dysfunction therefore results in severe endocrine disorders. Although recent experiments have ...
Human stem cell-derived organoid culture enables the in vitro analysis of the cellular function in three-dimensional aggregates mimicking native organs, and also provides a valuable source of specific cell types in the human body. We previously es...
Yu Kodani   Miho Kawata   Hidetaka Suga   Yoko S Kaneko   Akira Nakashima   Toshiki Kameyama   Kanako Saito   Hiroshi Nagasaki   
eNeuro 2022年4月
Hypothalamic melanin-concentrating hormone (MCH) neurons are important regulators of multiple physiological processes, such as sleep, feeding, and memory. Despite the increasing interest in their neuronal functions, the molecular mechanism underly...
Journal of neural transmission (Vienna, Austria : 1996) 2020年8月 [査読有り]
5'-Nucleotidase domain-containing protein 2 (NT5DC2) has been revealed by genome-wide association studies (GWAS) as a gene implicated in neuropsychiatric disorders related to the abnormality of dopamine (DA) activity in the brain. Based on its ami...
Akira Nakashima   Hisateru Yamaguchi   Yu Kodani   Yoko S Kaneko   Miho Kawata   Hiroshi Nagasaki   Toshiharu Nagatsu   Akira Ota   
Biochemical and biophysical research communications 516(4) 1060-1065 2019年9月 [査読有り]
Tyrosine hydroxylase (TH), which catalyzes the conversion of l-tyrosine to l-DOPA, is the rate-limiting enzyme in the biosynthesis of catecholamines. It is well known that both α-synuclein and 14-3-3 protein family members bind to the TH molecule ...